Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation
Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation
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DOI：
10.1161/01.atv.19.12.2863
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发表时间：
1999-12-01
影响因子：
8.7
通讯作者：
Collen, D
中科院分区：
文献类型：
--
作者：
Lijnen, HR;Van Hoef, B;Collen, D
The hypothesis that stromelysin-3 (MMP-11), a unique member of the matrix metalloproteinase (MMP) family, plays a role in neointima formation was tested with the use of a vascular injury model in wild-type (MMP-11(+/+)) and MMP-11-deficient (MMP-11(-/-)) mice. Neointima formation 2 to 3 weeks after electric injury of the femoral artery was significantly enhanced in MMP-11-/- as compared with MMP-11(+/+) mice, in both mice of a pure 129SV genetic background (0.014 versus 0.0010 mm(2) at 2 weeks, P
