Sleep-EEG modulation of interictal epileptiform discharges in adult partial epilepsy: a spectral analysis study
Sleep-EEG modulation of interictal epileptiform discharges in adult partial epilepsy: a spectral analysis study
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DOI：
10.1016/s1388-2457(00)00246-7
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发表时间：
2000-05-01
影响因子：
4.7
通讯作者：
Nobili, L
中科院分区：
文献类型：
--
作者：
Ferrillo, F;Beelke, M;Nobili, L
简介：为了准确定义脑电成分之间的关系，对部分性癫痫患者睡眠中发作间期癫痫样放电（LED）的发生率、睡眠中发作间期EEG的频率（纺锤波、δ和θ频率）与夜间放电分布进行相关性研究。（平均年龄：24.7 +/- 5.5岁）受部分癫痫影响的患者接受了连续的EEC-多导睡眠图。慢波活动（SWA），西格玛活动（SA）和θ带（TB）的时间序列，从频谱分析，获得了一个无尖峰和病理性变化的衍生，对侧的最活跃的铅，其中IED计数进行。结果：12名受试者的IED与SWA之间存在显著的相关性，3名受试者的ZED与SA之间存在显著的相关性，3名受试者的ZED与TB之间存在显著的相关性。结论：数据表明，在大多数成年患者部分癫痫IED生产过程中的睡眠是促进行动的同步机制，这是活跃在NREM睡眠，并导致EEG δ波的外观。然而，有证据表明，有两个较小的患者群体。在其中一个中，ZED对纺锤体产生机制的促进作用更敏感，在NREM睡眠的第2阶段活跃。在另一种情况下，TB的促进作用，表征了第1阶段和REM睡眠期间的EEG，是明显的。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Introduction: In order to define accurately the relationship between EEG components (spindles, delta and theta frequencies) and the occurrence of interictal epileptiform discharges (LED) during sleep in partial epilepsy, a correlation study between spike overnight distribution and EEG spectral power time series was performed.Methods: Eighteen patients (mean age: 24.7 +/- 5.5 years) affected by partial epilepsy underwent continuous EEC-polysomnography. The temporal series of Slow Wave Activity (SWA), Sigma Activity (SA) and Theta Band (TB), derived from spectral analysis, were obtained from a spike-free and pathologic alteration-free derivation, contralateral to the most active lead, where the IED count was performed. Relationships between SA, SWA and TB and time series of ZED were tested by means of correlation techniques after data normalization.Results: Our results revealed a significantly higher correlation between IED and SWA in 12 subjects; a significantly higher correlation between ZED and SA in three subjects and a significant correlation with TB in three cases.Conclusions: Data suggest that in most adult patients with partial epilepsy IED production during sleep is facilitated by the action of synchronizing mechanisms which are active during NREM sleep and lead to the appearance of EEG delta waves. Nevertheless evidence is given of two smaller groups of patients. In one of them ZED are more sensitive to the promoting action of the spindle generating mechanism, active during stage 2 of NREM sleep. In the other one the promoting action of TB, characterizing EEG during stage 1 and REM sleep, is evident. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.