Longitudinal changes in free-water within the substantia nigra of Parkinson's disease
Longitudinal changes in free-water within the substantia nigra of Parkinson's disease
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DOI：
10.1093/brain/awv136
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发表时间：
2015-08-01
期刊：
影响因子：
14.5
通讯作者：
Vaillancourt, David E.
中科院分区：
文献类型：
--
作者：
Ofori, Edward;Pasternak, Ofer;Vaillancourt, David E.
有一个明确的需要，以开发非侵入性标记物黑质进展帕金森氏病。我们以前发现帕金森病患者的黑质自由水水平升高，与单部位和多部位队列的对照组相比。在这里，我们测试的假设，在帕金森氏病的黑质中的自由水水平增加1年后的进展，在黑质中的基线自由水水平预测运动迟缓的变化后1年。我们在对照组（n = 19）和帕金森病患者（n = 25）中进行了纵向研究。在基线和1年后收集扩散成像和临床数据。使用盲法、手绘后黑质感兴趣区域对弥散成像数据进行游离水分析。组效应表明帕金森病患者后黑质的自由水值与对照组相比增加（P = 0.003），我们观察到显著的组x时间相互作用（P < 0.05）。1年后，帕金森病组的自由水值增加（P = 0.006），而对照组的自由水值没有变化。基线游离水值预测运动迟缓评分的1年变化（r = 0.74，P < 0.001）和蒙特利尔认知评估评分的1年变化（r =-0.44，P = 0.03）。帕金森病患者后黑质中的游离水升高，随着帕金森病的进展而增加，并预测运动迟缓和认知状态在1年内的后续变化。这些发现表明，自由水提供了一个潜在的非侵入性进展标记的黑质。
There is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson's disease. We previously found elevated free-water levels in the substantia nigra for patients with Parkinson's disease compared with controls in single-site and multi-site cohorts. Here, we test the hypotheses that free-water levels in the substantia nigra of Parkinson's disease increase following 1 year of progression, and that baseline free-water levels in the substantia nigra predict the change in bradykinesia following 1 year. We conducted a longitudinal study in controls (n = 19) and patients with Parkinson's disease (n = 25). Diffusion imaging and clinical data were collected at baseline and after 1 year. Free-water analyses were performed on diffusion imaging data using blinded, hand-drawn regions of interest in the posterior substantia nigra. A group effect indicated free-water values were increased in the posterior substantia nigra of patients with Parkinson's disease compared with controls (P = 0.003) and we observed a significant group x time interaction (P < 0.05). Free-water values increased for the Parkinson's disease group after 1 year (P = 0.006), whereas control free-water values did not change. Baseline free-water values predicted the 1 year change in bradykinesia scores (r = 0.74, P < 0.001) and 1 year change in Montreal Cognitive Assessment scores (r = -0.44, P = 0.03). Free-water in the posterior substantia nigra is elevated in Parkinson's disease, increases with progression of Parkinson's disease, and predicts subsequent changes in bradykinesia and cognitive status over 1 year. These findings demonstrate that free-water provides a potential non-invasive progression marker of the substantia nigra.