Long-term UVA eye irradiation causes decreased learning ability in mice
Long-term UVA eye irradiation causes decreased learning ability in mice
复制标题
长期UVA眼睛照射导致小鼠学习能力下降
DOI：
10.1111/phpp.12229
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
E.Kasahara
中科院分区：
文献类型：
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作者：
K.Hiramoto;E.Kasahara
研究背景长期的紫外线A（UVA）眼部照射可使大脑海马细胞变性。然而，对小鼠记忆和学习能力的影响尚不清楚。我们照射的眼睛或背部皮肤的小鼠与UVA在110 kJ/m2的剂量使用FL 20 SBLB ‐A灯为6，12，和24 months.ResultsThe平均逃避潜伏期在水迷宫中的UVA照射的小鼠相比，在控制中看到的显着增加。UVA眼部照射24个月的小鼠，记忆和学习能力下降明显。UVA眼睛照射小鼠脑中的乙酰胆碱酯酶活性、胆碱乙酰转移酶活性和乙酰胆碱含量显著低于对照小鼠。此外，在UVA眼部照射期间，β-淀粉样蛋白（Aβ）、产生Aβ肽的γ-分泌酶和晚期糖基化终产物的水平增加。此外，UVA眼睛照射的影响随着照射时间的增加（或老化），并引入葡萄糖进入大脑也减少与UVA眼睛irradiation.ConclusionsThese结果表明，UVA眼睛照射诱导小鼠的记忆和学习能力下降。
BackgroundLong‐term eye radiation with ultraviolet A (UVA) denatures the cells of the cerebral hippocampus. However, the influence on memory and learning ability in mice is not known.MethodsHR‐1 mice were used. We irradiated the eyes or dorsal skin of the mice with UVA at a dose of 110 kJ/m2using an FL20SBLB‐A lamp for 6, 12, and 24 months.ResultsThe mean escape latency in the water maze was significantly increased in the UVA‐irradiated mice in comparison with that seen in the controls. In the mice in which UVA eye irradiation was performed for 24 months, the depression of memory and learning ability was remarkable. The acetylcholinesterase activity, choline acetyltransferase activity, and acetylcholine content in the brain in the UVA eye‐irradiated mice were significantly less than those observed in the control mice. Furthermore, during UVA eye irradiation, the levels of β‐amyloid (Aβ), γ‐secretase, which produces Aβ peptide, and advanced glycation end products increased. Moreover, the effects of UVA eye irradiation increased with the duration of irradiation (or aging), and the introduction of glucose into the brain also decreased with UVA eye irradiation.ConclusionsThese results indicate that UVA eye irradiation induces a decreased memory and learning ability in mice.