Influence of the Transmetalating Agent in Difficult Coupling Reactions: Control in the Selectivity of C-F Bond Activation by Ni(0) Complexes in the Presence of AlMe3
Influence of the Transmetalating Agent in Difficult Coupling Reactions: Control in the Selectivity of C-F Bond Activation by Ni(0) Complexes in the Presence of AlMe3
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DOI：
10.1021/acs.organomet.7b00165
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发表时间：
2017-04-10
期刊：
影响因子：
2.8
通讯作者：
Johnson, Samuel A.
中科院分区：
文献类型：
--
作者：
Baird, Drake A.;Jamal, S.;Johnson, Samuel A.
虽然Ni(PEt3)(4)在室温下不与二氟或三氟芳烃反应，但当加入AlMe3等铝烃时，立即发生反应，从C-F键活化和易位生成AlMe2F和Ni(II)配合物。在这些体系中，额外的Lewis碱性化合物(如吡啶)对选择性的影响使我们能够深入了解交叉偶联反应中的选择性是如何由转金属剂控制的，以及氧化加成和转金属反应步骤不一定是不同的。
Although Ni(PEt3)(4) does not react with di- or trifluoroarenes at room temperature, upon the addition of aluminum hydrocarbons such as AlMe3 an immediate reaction occurs, to give AlMe2F and Ni(II) complexes from C-F bond activation and transmetalation. The influence of additional Lewis basic compounds, such as pyridine, on selectivity in these systems provides insight into how selectivity in a cross-coupling reaction is controlled by the transmetalating agent and how the oxidative addition and transmetalation steps are not necessarily distinct.