Resisting emotional interference: brain regions facilitating working memory performance during negative distraction.
Resisting emotional interference: brain regions facilitating working memory performance during negative distraction.
复制标题
DOI：
10.3758/cabn.10.2.159
复制
发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Anticevic A;Repovs G;Barch DM
即使在积极的认知参与过程中，与生存相关的信息也有特权进入我们的意识。先前的研究表明，在工作记忆（WM）中，负面情绪干扰会破坏外侧前额叶区域的激活，同时也会激活杏仁核。在这里，使用慢事件相关的功能磁共振成像，我们复制和扩展以前的工作，检查负面情绪分心对WM的影响：（1）我们证明，前额叶区域显示激活之间的差异，正确和不正确的试验在负面的，但不是中性的，分心。具体来说，在负性分心时，额极前额叶皮层表现出更多的失活，而腹外侧前额叶皮层则表现出较少的激活;（2）杏仁核活动的个体差异预测了负性分心和中性分心时的工作记忆表现，即较低的活动预测了较好的表现;（3）静息状态下杏仁核与前额叶和顶叶皮层呈负相关。然而，在负性分心，杏仁核信号与前额叶皮层区域的负相关性比发现休息状态和中性分心。这些结果进一步证明，当处理厌恶刺激与正在进行的认知操作竞争时，背侧前额叶皮质区和杏仁核之间存在反向关系，并进一步支持前额叶皮质在抵抗情绪干扰方面的重要性。
Survival-relevant information has privileged access to our awareness even during active cognitive engagement. Previous work has demonstrated that during working memory (WM) negative emotional distraction disrupts activation in the lateral prefrontal regions while also engaging the amygdala. Here, using slow event-related fMRI, we replicate and extend previous work examining the effect of negative emotional distraction on WM: (1) We demonstrate that prefrontal regions showed activation differences between correct and incorrect trials during negative, but not neutral, distraction. Specifically, frontopolar prefrontal cortex showed more deactivation for incorrect trials faced with negative distraction, whereas ventrolateral prefrontal regions showed less activation; (2) individual differences in amygdala activity predicted WM performance during negative as well as neutral distraction, such that lower activity predicted better performance; and (3) amygdala showed negative correlations with prefrontal and parietal cortical regions during resting state. However, during negative distraction, amygdala signals were more negatively correlated with prefrontal cortical regions than was found for resting state and neutral distraction. These results provide further evidence for an inverse relationship between dorsal prefrontal cortical regions and the amygdala when processing aversive stimuli competes with ongoing cognitive operations, and further support the importance of the prefrontal cortex in resisting emotional interference.