Evaluation of a commercially available Zika virus IgM ELISA: specificity in focus
Evaluation of a commercially available Zika virus IgM ELISA: specificity in focus
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DOI：
10.1016/j.diagmicrobio.2017.04.002
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发表时间：
2017-07-01
影响因子：
2.9
通讯作者：
Racano, Adrianna
中科院分区：
文献类型：
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作者：
Kadkhoda, Kamran;Gretchen, Ainsley;Racano, Adrianna
寨卡病毒（ZIKV）是一种新兴的虫媒病毒，由于与先天性异常有关，已成为人们关注的中心。考虑到ZIKV疾病与其他传染病的重叠临床表现，并且作为紧急的公共卫生问题，及时和可靠地诊断ZIKV感染是至关重要的。我们评估了市售的基于NSl的ZIKV IgM ELISA的性能。我们的研究结果显示，在发病后的前5天内，敏感性不佳，而特异性仍然很强。皇冠版权所有（C）2017由Elsevier Inc. All rights reserved.
Zika virus (ZIKV), an emerging arbovirus, has become the center of attention since it was linked to congenital abnormalities. Given the overlapping clinical picture of ZIKV disease with other infectious diseases and as an exigent public health matter, timely and reliable diagnosis of ZIKV infection is crucial. We evaluated the performance of a commercially available NS1-based ZIKV IgM ELISA. Our results showed suboptimal sensitivity within the first 5 days after onset while specificity remained robust. Crown Copyright (C) 2017 Published by Elsevier Inc. All rights reserved.