Bronchogenic Carcinoma after Lung Transplantation: Characteristics and Outcomes
Bronchogenic Carcinoma after Lung Transplantation: Characteristics and Outcomes
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DOI：
10.1097/jto.0b013e31818e1259
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发表时间：
2008-12-01
影响因子：
20.4
通讯作者：
Mehta, Atul C.
中科院分区：
文献类型：
--
作者：
Minai, Omar A.;Shah, Sonia;Mehta, Atul C.
背景：肺癌可能发生在肺移植人群中，因为许多患者以前吸烟。我们对这些patients.Methods的风险因素和结果知之甚少：我们在我们的机构进行了肺移植数据库的搜索，以确定已被诊断为癌症的患者。审查记录和报告的人口统计学资料、恶性肿瘤的风险因素。结果：我们确定了12例支气管肺癌肺移植患者[年龄47.2 ± 13.2岁（平均值± SD）：7例（58%）男性和5例（42%）女性]。11例患者因慢性阻塞性肺疾病（COPD）接受移植。从移植到诊断癌症的时间为119（21-416）[平均（范围）]周。11种癌症发生在原生肺中，最常见的癌细胞类型是腺癌（N = 5）。接受单肺移植的COPD患者的发病率为5.15%。支气管肺癌诊断至死亡的时间为10.8（1-60）周，1年死亡率为75%（9/12）。结论：在我们的患者中，几乎所有的肺癌都发生在因COPD接受肺移植的戒烟者的自体肺中。癌症通常在常规胸片上偶然发现;然而，该疾病通常在诊断时处于晚期，限制了治疗选择。
Background: Lung cancer may Occur in the lung transplant population because many patients are former smokers. Not much is known about risk factors and outcomes in these patients.Methods: We performed a search of the lung transplant database at our institution to identify patients who had been diagnosed with cancer. Records and reports were reviewed for demographics, risk factors for malignancy. lung transplant characteristics, radiographic characteristics, treatment, and outcomes.Results: We identified 12 lung transplant patients with bronchogenic carcinoma at our institution [age 47.2 +/- 13.2 years (mean +/- SD): 7 (58%) men and 5 (42%) women]. Eleven patients were transplanted for chronic obstructive pulmonary disease (COPD) Time from transplantation to diagnosis of cancer was 119 (21-416) [mean (range)] weeks. Eleven cancers occurred in the native lung most common cancer cell types were adenocarcinoma (N = 5). Incidence among patients with COPD, who received single lung transplantation was 5.15%. Time frorn diagnosis of bronchogenic carcinoma to death was 10.8 (1-60) [mean (range)] weeks with a 75% (9/12) 1-year mortality.Conclusions: Among our patients, almost all cancers Occurred in native lung in ex-smokers who received a lung transplant for COPD. The cancer was often in incidental finding on a routine chest radiograph; however, the disease was Usually at an advanced stage at diagnosis, limiting therapeutic options.