Deceiving others: Distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions
Deceiving others: Distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions
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DOI：
10.1162/jocn.2007.19.2.287
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发表时间：
2007-02-01
影响因子：
3.2
通讯作者：
Fujii, Toshikatsu
中科院分区：
文献类型：
--
作者：
Abe, Nobuhito;Suzuki, Maki;Fujii, Toshikatsu
最近，人们利用功能性磁共振成像和正电子发射断层扫描等神经成像技术对说谎的大脑机制进行了研究。尽管这些技术的出现逐渐阐明了前额叶皮层在欺骗中执行功能的功能贡献，但前额叶皮层内的子区域和其他负责欺骗期间情绪调节或社会互动的大脑区域的具体作用仍不清楚。假设伪造真实反应和欺骗他人的过程与这些区域的活动存在差异，我们进行了 2（真相，谎言）x 2（诚实，不诚实）因子设计的正电子发射断层扫描实验。伪造真实反应的主要影响揭示了左背外侧和右前前额皮质的大脑活动增加，支持了先前研究的解释，即执行功能与做出不真实的反应有关。欺骗审讯者的主要影响显示了腹内侧前额叶（内侧眶额）皮层和杏仁核的激活，这增加了新的证据，表明在欺骗行为期间负责情绪处理或社交互动的大脑区域与现实生活中的情况相似。进一步的分析显示，右前额叶皮层的活动显示出欺骗的两种作用，表明该区域在说谎方面起着关键作用。我们的研究结果提供了前额叶分区和杏仁核在人类欺骗中功能分离作用的明确证据。
Brain mechanisms for telling lies have been investigated recently using neuroimaging techniques such as functional magnetic resonance imaging and positron emission tomography. Although the event of these techniques has gradually enabled clarification of the functional contributions of the prefrontal cortex in the deception with respect to executive function, the specific roles of subregions within the prefrontal cortex and other brain regions responsible for emotional regulation or social interactions during deception are still unclear. Assuming that the processes of falsifying truthful responses and decieving others are differential associated with the activities of these regions, we conducted a positron emission tomography experiment with 2 (truth, lie) x 2 (honesty, dishonesty) factorial design. The main effect of falsifying the truthful responses revealed increased brain activity of the left dorsolateral and right anterior prefrontal cortices, supporting the interpretation of previous studies that executive functions are related to making untruthful responses. The main effects of decieving the interrogator showed activations of the ventromedial prefrontal (medial orbitofrontal) cortex and amygdala, adding new evidence that the brain regions assumed to be responsible for emotional processing or social interaction are active during deceptive behaviour similar to that in real-life situations. Further analysis revealed that activity on the right anterior prefrontal cortex showed both effects of deception, indicating that this region has a privotal role in telling lies. Our results provide clear evidence of functionally dissociable roles of prefrontal subregions and amygdala for human deception.