Hypoxia inducible factor-1-independent pathways in tumor angiogenesis
Hypoxia inducible factor-1-independent pathways in tumor angiogenesis
复制标题
DOI：
10.1158/1078-0432.ccr-07-0111
复制
发表时间：
2007-10-01
影响因子：
11.5
通讯作者：
Chung, Daniel C.
中科院分区：
文献类型：
--
作者：
Mizukami, Yusuke;Kohgo, Yutaka;Chung, Daniel C.
在能够刺激血管生成的因子中，血管内皮生长因子已经成为最重要的因子之一，并且抑制血管内皮生长因子最近在晚期结直肠癌的治疗中显示出有效性。缺氧在实体瘤中发展，并且是血管内皮生长因子表达的最有效刺激物之一。这种作用主要由缺氧诱导因子-1（HIF-1）介导，其通常被认为是缺氧中血管生成的主要调节因子。因此，已经提出抑制HIF-1作为治疗性阻断肿瘤血管生成的策略。然而，越来越多的证据表明，HIF非依赖性途径也可以控制血管生成。这篇综述强调了一些关键的信号通路，独立于HIF-1，可以刺激缺氧血管生成。了解控制肿瘤血管生成的分子途径的全谱对于靶向治疗的最佳设计至关重要。
Among the factors that can stimulate angiogenesis, vascular endothelial growth factor has emerged as one of the most important, and inhibition of vascular endothelial growth factor has recently shown efficacy in the treatment of advanced colorectal cancer. Hypoxia develops within solid tumors and is one of the most potent stimuli of vascular endothelial growth factor expression. This effect is mediated primarily by hypoxia inducible factor-1 (HIF-1), often considered a master regulator of angiogenesis in hypoxia. Consequently, inhibition of HIF-1 has been proposed as a strategy to block tumor angiogenesis therapeutically. However, accumulating evidence indicates that HIF-independent pathways can also control angiogenesis. This review highlights some of the key signaling pathways independent of HIF-1 that can stimulate angiogenesis in hypoxia. Understanding the full spectrum of molecular pathways that control tumor angiogenesis is critical for the optimal design of targeted therapies.