Standardized uptake values of fluorine-18 fluorodeoxyglucose: The value of different normalization procedures
Standardized uptake values of fluorine-18 fluorodeoxyglucose: The value of different normalization procedures
复制标题
DOI：
10.1007/bf00833394
复制
发表时间：
1996-05-01
期刊：
影响因子：
--
通讯作者：
Biersack, HJ
中科院分区：
文献类型：
--
作者：
Schomburg, A;Bender, H;Biersack, HJ
虽然绝对代谢率测定的明显优势不能与氟-18氟脱氧葡萄糖正电子发射断层扫描（FDG PET）研究的静态图像分析相媲美，但已提出了用于静态FDG摄取值归一化的各种算法。本研究旨在比较不同标准化程序对个体患者特征的依赖性。标准化FDG摄取值（SUV）计算126例患者的肝脏和肺组织与全身FDG PET研究。将摄取值针对总体重、瘦体重和体表面积进行标准化。计算这些SUV参数的范围、平均值、中位数、标准差和变异系数，并通过回归分析计算它们与总体重、瘦体重、体表面积、患者身高和血糖水平的相互依赖性。以体表面积标准化的标准化FDG摄取值明显优于以总体重或瘦体重标准化的SUV参数上级。变异和相关系数的体表面积标准化摄取值是最小的SUV参数相比，来自其他标准化程序。总体重的标准化导致摄取值仍然依赖于体重和血糖水平，而瘦体重的标准化并没有消除与瘦体重和患者身高的正相关性。它的结论是，正常化的FDG摄取值的体表面积是不太依赖于个体患者的特征比FDG摄取值正常化的其他参数，因此似乎是最好的FDG PET研究肿瘤。
While the evident advantages of absolute metabolic rate determinations cannot be equalled by static image analysis of fluorine-18 fluorodeoxyglucose positron emission tomographic (FDG PET) studies, various algorithms for the normalization of static FDG uptake values have been proposed. This study was performed to compare different normalization procedures in terms of dependency on individual patient characteristics. Standardized FDG uptake values (SUVs) were calculated for liver and lung tissue in 126 patients studied with whole-body FDG PET. Uptake values were normalized for total body weight, lean body mass and body surface area. Ranges, means, medians, standard deviations and variation coefficients of these SUV parameters were calculated and their interdependency with total body weight, lean body mass, body surface area, patient height and blood sugar levels was calculated by means of regression analysis. Standardized FDG uptake values normalized for body surface area were clearly superior to SUV parameters normalized for total body weight or lean body mass. Variation and correlation coefficients of body surface area-normalized uptake values were minimal when compared with SUV parameters derived from the other normalization procedures. Normalization for total body weight resulted in uptake values still dependent on body weight and blood sugar levels, while normalization for lean body mass did not eliminate the positive correlation with lean body mass and patient height. It is concluded that normalization of FDG uptake values for body surface area is less dependent on the individual patient characteristics than are FDG uptake values normalized for other parameters, and therefore appears to be preferable for FDG PET studies in oncology.