Synaptic plasticity in the mormyrid electrosensory lobe.
Synaptic plasticity in the mormyrid electrosensory lobe.
复制标题
斑尾鱼电感觉叶的突触可塑性。
DOI：
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复制
发表时间：
1999
影响因子：
2.8
通讯作者：
Kirsty Grant
中科院分区：
文献类型：
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作者：
Curtis C. Bell;Victor Z. Han;Yoshiko Sugawara;Kirsty Grant
鱼的电感觉侧线叶（ELL）是鱼类的几种不同的感觉结构之一，表现为适应性感觉处理器。这些结构在感觉流入中产生可预测特征的负像，这些负像被添加到实际流入中以最小化可预测感觉特征的影响。负面图像是通过中枢产生的预测信号和来自外围的感觉输入之间的关联过程产生的。在离体的研究表明，在mormyrid ELL的平行纤维输入与突触后细胞中的Na+锋电位配对的结果在平行纤维突触的突触抑制。在细胞水平上观察到的突触可塑性和在系统水平上产生预测感觉输入的负面图像的关联过程共享许多特性。两者都是快速建立的，反赫布，可逆的，输入特定的和严格限制的时间。这些共同的属性强烈认为，在平行的纤维突触的联想抑郁症有助于适应性生成的负面形象在mormyrid ELL。
The mormyrid electrosensory lateral line lobe (ELL) is one of several different sensory structures in fish that behave as adaptive sensory processors. These structures generate negative images of predictable features in the sensory inflow which are added to the actual inflow to minimize the effects of predictable sensory features. The negative images are generated through a process of association between centrally originating predictive signals and sensory inputs from the periphery. In vitro studies in the mormyrid ELL show that pairing of parallel fiber input with Na+ spikes in postsynaptic cells results in synaptic depression at the parallel fiber synapses. The synaptic plasticity observed at the cellular level and the associative process of generating negative images of predicted sensory input at the systems level share a number of properties. Both are rapidly established, anti-Hebbian, reversible, input-specific and tightly restricted in time. These common properties argue strongly that associative depression at the parallel fiber synapse contributes to the adaptive generation of negative images in the mormyrid ELL.