SHORT-TERM INCREASE IN RISK OF BREAST-CANCER AFTER FULL TERM PREGNANCY
SHORT-TERM INCREASE IN RISK OF BREAST-CANCER AFTER FULL TERM PREGNANCY
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DOI：
10.1136/bmj.297.6656.1096
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发表时间：
1988-10-29
影响因子：
105.7
通讯作者：
DELTURCO, MR
中科院分区：
文献类型：
--
作者：
BRUZZI, P;NEGRI, E;DELTURCO, MR
为了确定足月分娩后是否会在短期内增加患乳腺癌的风险，我们汇集了意大利两家医院的病例对照研究数据。分析仅限于50岁以下有两个或两个以上孩子的女性（573名癌症女性和570名对照组）。在对年龄、第一胎年龄和胎次进行调整后，在访谈前三年内分娩的妇女与在访谈前10年或更长时间分娩的妇女相比，患乳腺癌的相对风险为2.66。对于上次分娩时间在3到10年前的女性来说，相对风险会缓慢下降。多变量分析证实了早生第一胎的保护作用和胎次对乳腺癌风险的年龄依赖效应，也就是说，40岁以下的女性与年龄成正比，而在年龄较大的女性中则成反比。这些数据提供的流行病学证据表明，足月分娩后，乳腺癌风险会短暂增加，这在一段时间内与早期妊娠的长期保护形成对比，并使之无法实现。因此，他们证实了动物研究和理论模型的预测，即怀孕可以防止乳腺癌发生的早期阶段，但会促进该过程的后期阶段。
To determine whether there is a short term increase in the risk of breast cancer after a full term birth data from two hospital based, case-control studies in Italy were pooled. Analysis was restricted to women aged under 50 with two or more children (573 women with cancer and 570 controls). A relative risk for breast cancer of 2.66 was seen in women who had given birth during the three years preceding the interview compared with women whose last birth had occurred 10 or more years before, after adjustment for age, age at first birth, and parity. The relative risk slowly decreased for women who had last given birth three to 10 years before. Multivariate analyses confirmed the protective effect of an early age at first birth and the age dependent effect of parity on the risk of breast cancer-that is, a direct relation below age 40 and an inverse one in older women. These data provide epidemiological evidence that a full term birth is followed by a transient increase in the risk of breast cancer, which for some time contrasts with and overcomes the long term protection of pregnancy at an early age. They therefore confirm predictions from animal studies and theoretical models that pregnancy prevents the early stages of breast carcinogenesis but promotes the late stages of the process.