30-Year Longitudinal Study of Hematological Parameters of HIV-1 Negative Men Participating in Los Angeles Multicenter AIDS Cohort Study (MACS)
30-Year Longitudinal Study of Hematological Parameters of HIV-1 Negative Men Participating in Los Angeles Multicenter AIDS Cohort Study (MACS)
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DOI：
10.1093/labmed/lmy044
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发表时间：
2019-02-01
影响因子：
1.3
通讯作者：
Detels, Roger
中科院分区：
文献类型：
--
作者：
Aziz, Najib;Quint, Joshua J.;Detels, Roger
背景临床医生在解释患者结果时经常使用基于总体的参考间隔(RIS)。方法对82名非西班牙裔白人男性进行30年来每6个月检测一次常规血液学标志物的生物学变异，以确定基于人群的RIS的有效性和血液学标志物的年龄相关性下降。结果许多血液学标志物存在显著的人与人之间的差异(个性指数
Background Clinicians often use population-based reference intervals (RIs) when interpreting patient results. However, this method can present problems if the analyte in question has wide variability from person to person.Methods We examined the biological variation of routine hematologic markers in 82 white non-Hispanic men every 6 months during a 30-year period, to determine the usefulness of population-based RIs and age-related decline of hematological markers.Results Many of these markers showed significant person-to-person differences (index of individuality