Targeted radionuclide therapy for solid tumors: An overview
Targeted radionuclide therapy for solid tumors: An overview
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DOI：
10.1016/j.ijrobp.2006.03.066
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发表时间：
2006-01-01
影响因子：
7
通讯作者：
DeNardo, Gerald L.
中科院分区：
文献类型：
--
作者：
DeNardo, Sally J.;DeNardo, Gerald L.
尽管放射免疫治疗(RIT)作为一种单一药物对非霍奇金淋巴瘤(NHL)有效，但实体瘤单独使用RIT的临床疗效较差。RIT或其他形式的靶向放射性核素治疗实体肿瘤的临床效果取决于肿瘤相对于正常组织效应的高治疗指数(TI)的开发，以及RIT作为协同联合模式治疗(CMRIT)的一部分的实施。临床前和临床研究提供了丰富的信息，新的原型或范例在许多情况下阐明了未来的可能性。有证据表明，在CMRIT中适当地结合和测序RIT可以为许多实体肿瘤提供有效的治疗。血管靶点提供了增强RIT的机会，纳米颗粒可能被证明是RIT结合细胞内药物输送或交变磁场(AMF)诱导的热性肿瘤坏死的有效载体。联合治疗的顺序和时机对于实现治疗的协同作用，同时将毒性降至最低至关重要。幸运的是，用于RIT的放射性核素也提供了一个有用的信号，用于无损定量CMRIT的序列和时机对动物和患者事件的影响。这可以很容易地在临床上使用定量高分辨率成像(例如，正电子发射断层扫描[PET])来实现。(C)2006年爱思唯尔公司。
Although radioimmunotherapy (RIT) has been effective in non-Hodgkin's lymphoma (NHL) as a single agent, solid tumors have shown less clinically significant therapeutic response to RIT alone. The clinical impact of RIT or other forms of targeted radionuclide therapy for solid tumors depends on the development of a high therapeutic index (TI) for the tumor vs. normal tissue effect, and the implementation of RIT as part of synergistic combined modality therapy (CMRIT). Preclinical and clinical studies have provided a wealth of information, and new prototypes or paradigms have shed light on future possibilities in many instances. Evidence suggests that combination and sequencing of RIT in CMRIT appropriately can provide effective treatment for many solid tumors. Vascular targets provide RIT enhancement opportunities and nanoparticles may prove to be effective carriers for RIT combined with intracellular drug delivery or alternating magnetic frequency (AMF) induced thermal tumor necrosis. The sequence and timing of combined modality treatments will be of critical importance to achieve synergy for therapy while minimizing toxicity. Fortunately, the radionuclide used for RIT also provides a signal useful for nondestructive quantitation of the influence of sequence and timing of CMRIT on events in animals and patients. This can be readily accomplished clinically using quantitative high-resolution imaging (e.g., positron emission tomography [PET]). (c) 2006 Elsevier Inc.