The Roles of Peroxiredoxin 6 in Brain Diseases
The Roles of Peroxiredoxin 6 in Brain Diseases
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DOI：
10.1007/s12035-021-02427-5
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发表时间：
2021-05-19
影响因子：
5.1
通讯作者：
Zhang, Jing
中科院分区：
文献类型：
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作者：
Liao, Jiangfeng;Zhang, Yusi;Zhang, Jing
过氧化物还原酶6（PRDX6）是过氧化物还原酶（PRDXs）家族中哺乳动物特有的单半胱氨酸成员，具有谷胱甘肽过氧化物酶（Gpx）活性、酸性钙离子非依赖型磷脂酶（aiPLA2）活性以及溶血磷脂酰胆碱酰基转移酶（LPCAT）活性等多种功能。已有研究表明，它参与氧化还原稳态、磷脂周转、糖脂代谢以及细胞信号传导。在此，我们综述了现有的Prdx6基因敲除小鼠模型的特点，以及PRDX6在神经精神疾病方面的研究进展，这些疾病包括神经退行性疾病、脑老化、中风、神经创伤、胶质瘤、重度抑郁症、药物成瘾、创伤后应激障碍和精神分裂症。本综述着重强调了PRDX6在神经精神疾病中的重要作用，可能为开发有效的药物治疗和基因治疗提供新的思路。
Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxins (PRDXs) family, has multiple functions of glutathione peroxidase (Gpx) activity, acidic calcium-independent phospholipase (aiPLA2) activity, and lysophosphatidylcholine acyl transferase (LPCAT) activity. It has been documented to be involved in redox homeostasis, phospholipid turnover, glycolipid metabolism, and cellular signaling. Here, we reviewed the characteristics of the available Prdx6 genetic mouse models and the research progresses made with regard to PRDX6 in neuropsychiatric disorders, including neurodegenerative diseases, brain aging, stroke, neurotrauma, gliomas, major depressive disorder, drug addiction, post-traumatic stress disorder, and schizophrenia. The present review highlights the important roles of PRDX6 in neuropsychiatric disorders and may provide novel insights for the development of effective pharmacological treatments and genetic therapies.