BCG VACCINATION AGAINST TUBERCULOSIS AND LEPROSY
BCG VACCINATION AGAINST TUBERCULOSIS AND LEPROSY
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DOI：
10.1093/oxfordjournals.bmb.a072277
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发表时间：
1988-07-01
影响因子：
6.7
通讯作者：
FINE, PEM
中科院分区：
文献类型：
--
作者：
FINE, PEM
本文综述了卡介苗的来源、使用、保护效果和公共卫生影响。本文参照各种假设来讨论评价其功效的问题，这些假设是为了解释在世界不同地区进行的研究中得出的不同估计。结论是，尽管保护效果有明显差异，但卡介苗的广泛使用（四十年来全世界超过30亿剂）意味着它们对结核病和麻风病产生了重大影响。解释卡介苗的不同保护作用的问题仍未得到解决，但由于卡介苗的使用规模和目前正在努力开发针对结核病和麻风病的改进疫苗，这一问题非常重要。
This paper reviews the origin, use, protective efficacy and public health impact of BCG vaccines. The problem of evaluating their efficacy is discussed with reference to various hypotheses which have been proposed to explain the divergent estimates obtained in studies carried out in different areas of the world. It is concluded that, despite the apparent variation in protective efficacy, the extensive use of BCG vaccines (more than three billion doses worldwide in four decades) means that they have had a substantial impact on tuberculosis and leprosy. The problem of explaining BCG's varying protection remains unsolved but of great importance, because of the scale of BCG use and current effort to develop improved vaccines against tuberculosis and leprosy.