Prevalence and characteristics of MAFLD in Chinese adults aged 40 years or older: A community-based study
Prevalence and characteristics of MAFLD in Chinese adults aged 40 years or older: A community-based study
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中国40岁及以上成年人MAFLD的患病率和特征：基于社区的研究
DOI：
10.1016/j.hbpd.2022.01.006
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发表时间：
2022-04-01
影响因子：
3.3
通讯作者：
Fan, Jian-Gao
中科院分区：
文献类型：
--
作者：
Zeng, Jing;Qin, Li;Fan, Jian-Gao
背景：非酒精性脂肪肝病（NAFLD）最近被提议更名为代谢功能障碍相关脂肪肝病（MAFLD），并修订了诊断标准。我们调查了中国成人中 MAFLD 和 NAFLD 的患病率和临床特征的异同。方法：2011 年至 2012 年间，在中国上海采用随机分层整群抽样方法对 9980 名 40 岁或以上的中国个体进行了横断面研究。收集详细的调查问卷以及腹部超声检查、标准化2小时75克口服葡萄糖耐量试验和血液生化检查的结果。结果：本研究共纳入 9927 名受试者。 MAFLD的患病率（40.3%）显着高于NAFLD（36.9%）（P < 0.05）。 MAFLD 在 2 型糖尿病 (T2DM) (53.8%)、空腹血糖受损 (35.7%) 和糖耐量受损 (40.9%) 中非常常见。在患有 T2DM 的瘦 MAFLD 中，基于纤维化 4 的晚期纤维化的高风险非常普遍 (14.7%)。在 9927 名受试者中，3481 名 (35.1%) 符合 MAFLD 和 NAFLD (MAFLD + NAFLD + ) 的诊断标准，521 名 (5.2%) MAFLD + NAFLD- 和 181 名 (1.8%) MAFLD-NAFLD+ 。 MAFLD + NAFLD 组比 MAFLD + NAFLD + 组有更显着的代谢紊乱（均 P < 0.05）。在 MAFLD-NAFLD+ 受试者中，82.9% 患有代谢紊乱。结论：MAFLD的新定义可能更好地反映与代谢相关的发病机制。未来的研究应重点研究NAFLD和MAFLD受试者重叠和非重叠的自然史、发病机制和治疗效果。(C)2022中国浙江大学医学院附属第一医院。由 Elsevier B.V. 出版。保留所有权利。
Background: Nonalcoholic fatty liver disease (NAFLD) was recently proposed to be renamed metabolic dysfunction-associated fatty liver disease (MAFLD) with the diagnostic criteria revised. We investigated the similarities and differences in the prevalence and clinical characteristics of MAFLD and NAFLD in Chinese adults. Methods: A cross-sectional study of 9980 Chinese individuals aged 40 years or older was performed between 2011 and 2012 using randomized, stratified cluster sampling in Shanghai, China. A detailed questionnaire and the results of abdominal ultrasonography, a standardized 2-h 75-g oral glucose tolerance test and blood biochemical examinations were collected. Results: A total of 9927 subjects were included in this study. The prevalence of MAFLD (40.3%) was significantly higher than that of NAFLD (36.9%) ( P < 0.05). MAFLD was highly prevalent in type 2 diabetes mellitus (T2DM) (53.8%), impaired fasting glucose (35.7%) and impaired glucose tolerance (40.9%). High risk of advanced fibrosis based on fibrosis-4 was highly prevalent (14.7%) in lean MAFLD with T2DM. Among 9927 subjects, 3481 (35.1%) fulfilled the diagnostic criteria for MAFLD and NAFLD (MAFLD + NAFLD + ), 521 (5.2%) MAFLD + NAFLD-, and 181 (1.8%) MAFLD-NAFLD+ . The MAFLD + NAFLD-group had more significant metabolic disorders than those in the MAFLD + NAFLD+ group (all P < 0.05). Among MAFLD-NAFLD+ subjects, 82.9% had metabolic disorders. Conclusions: The new definition of MAFLD may better reflect the pathogenesis related to metabolism. Future research should focus on studying the natural history, pathogenesis and treatment effectivity of the overlap and non-overlap of NAFLD and MAFLD subjects.(C) 2022 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.