Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence - Case report
Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence - Case report
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DOI：
10.3171/jns.2007.106.6.1070
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发表时间：
2007-06-01
影响因子：
4.1
通讯作者：
Tsuji, Motomu
中科院分区：
文献类型：
--
作者：
Kajimoto, Yoshinaga;Kuroiwa, Toshihiko;Tsuji, Motomu
已经确定使用5-氨基乙酰丙酸（5-ALA）的荧光引导切除术在胶质瘤手术中是有用的。作者报告了一名65岁女性，患有巨大的非典型左半球脑膜瘤，该脑膜瘤延伸到颅骨和上级矢状窦，并在给予5-ALA后出现荧光。切除肿瘤后，在荧光手术显微镜系统的荧光模式下观察手术野。在静脉和静脉窦后面、部分肥厚硬脑膜和沿着颅骨边缘可见几个微小的肿瘤组织残留区域，显示为强荧光。这些残留物被完全清除。作者得出结论，使用5-ALA的荧光引导切除术在复发风险高的非典型脑膜瘤病例中有用。
It has been established that fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) is useful in glioma surgery. The authors report on a 65-year-old woman who had a huge atypical left-hemisphere meningioma, which extended into the skull and to the superior sagittal sinus and demonstrated fluorescence in response to administration of 5-ALA. After the tumor was removed, the operative field was observed under the fluorescent mode of a fluorescence surgical microscopy system. Several minute areas of residual tumor tissue were visualized as strong fluorescence behind the vein and sinus, in a part of the hypertrophic dura, and along the edge of the skull. These remnants were completely removed. The authors concluded that fluorescence-guided resection using 5-ALA is useful in cases of atypical meningiomas with a high risk of recurrence.