SENSITIZATION IN APLYSIA - RESTORATION OF TRANSMISSION IN SYNAPSES INACTIVATED BY LONG-TERM HABITUATION
SENSITIZATION IN APLYSIA - RESTORATION OF TRANSMISSION IN SYNAPSES INACTIVATED BY LONG-TERM HABITUATION
复制标题
DOI：
10.1126/science.451611
复制
发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
KANDEL, ER
中科院分区：
文献类型：
--
作者：
CAREW, T;CASTELLUCCI, VF;KANDEL, ER
长时间习惯性的简单的撤回反射在Aesalaads导致一个失活的突触之间的识别的感觉和鳃运动神经元，持续超过3周。一个单一的敏化刺激迅速重新激活压抑的行为反应和失活的突触传递。因此，敏感化，一种简单的竞争性学习形式，提供了一种机制，通过这种机制，不断变化的环境需求可以迅速压倒习惯化的长期记忆。
Long-term habituation of a simple withdrawal reflex inAplysialeads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation.