Failure of sympathetic stimulation to affect responsiveness of rabbit polymodal nociceptors.
Failure of sympathetic stimulation to affect responsiveness of rabbit polymodal nociceptors.
复制标题
交感神经刺激未能影响兔多模式伤害感受器的反应性。
DOI：
10.1152/jn.1985.54.3.513
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发表时间：
1985
影响因子：
2.5
通讯作者：
Perl,ER
中科院分区：
文献类型：
--
作者：
Shea,VK;Perl,ER
在间歇刺激和不刺激同侧颈交感干的情况下，观察了家兔耳大神经无髓（C）纤维的多模态伤害性感受器的反应。将每个多模态伤害感受器的感受野以5 ℃的步长以逐步方式从30 ℃加热到50 ℃或55 ℃两次。对于每个单元，一个加热试验是对照试验，另一个伴随交感神经刺激。控制和交感神经刺激试验的顺序和最高测试温度在检查的单位之间系统地变化。在交感神经刺激的存在下，在第一次加热试验中的多模态伤害感受器的初始反应类似于其第一次加热是对照试验的单元的反应。在第一次试验中，感受野被测试到最高温度为50摄氏度的单位在第二次试验中表现出对热的增强反应（敏化），而最初测试到55摄氏度的单位在第二次加热试验中反应不那么活跃（抑郁）。然而，在第二次加热试验中交感神经刺激的发生对敏感或抑制元件的热反应没有明显影响。个体单位的脉冲数、瞬时频率或脉冲活动模式的改变不能归因于交感神经刺激。（250字处删节）
The responses of polymodal nociceptors with unmyelinated (C) fibers of the rabbit's great auricular nerve were examined with and without intermittent stimulation of the ipsilateral cervical sympathetic trunk. The receptive field of each polymodal nociceptor was heated twice in a stepwise manner from 30 to 50 or 55 degrees C in 5 degree C steps. For each unit, one heating trial was a control trial and the other was accompanied by sympathetic stimulation. The order of the control and sympathetic stimulation trials and the maximum testing temperature were varied systematically among the units examined. The initial responses of polymodal nociceptors in the first heating trial in the presence of sympathetic stimulation were similar to the responses of units whose first heating was a control trial. Units whose receptive fields were tested to a maximum temperature of 50 degrees C in the first trial displayed enhanced responses to heat in their second trial (sensitization), while units tested initially to 55 degrees C responded less briskly during their second heating trial (depression). However, the occurrence of sympathetic stimulation in the second heating trials had no apparent effect on the responses to heat of sensitized or depressed elements. Alterations in the numbers of impulses, instantaneous frequency, or pattern of impulse activity of individual units could not be attributed to sympathetic stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)