Inhibitory interaction of receptor units in the eye of Limulus.
Inhibitory interaction of receptor units in the eye of Limulus.
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DOI：
10.1085/jgp.40.3.357
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发表时间：
1957-01-20
期刊：
影响因子：
--
通讯作者：
RATLIFF F
中科院分区：
文献类型：
--
作者：
HARTLINE HK;RATLIFF F
通过示波记录单个视神经纤维中神经冲动的放电，分析了鲎外侧眼中受体单元（小眼）之间相互施加的抑制。通过将包含视神经纤维的束连接到单独的放大器和记录系统，同时记录两个小眼的放电。选择的小眼在眼睛中的间隔不超过几毫米；它们由单独的光学系统独立照明。当两个小眼一起被照亮时，来自稳定照亮的两个小眼中的每一个的维持的脉冲放电频率低于每个小眼单独被照亮时的频率。当只有两个小眼被照亮时，每个小眼的抑制程度仅取决于另一个小眼的活动程度；反过来，每一个的活动都是其各自的光刺激的激发和另一个对其施加的抑制的结果。当另外的受体在相互作用的一对附近被照亮时，距离一个小眼太远而无法直接影响它，但又足够接近第二个小眼以抑制它，第一个受体的放电频率会增加，因为它部分地从第二个小眼对其施加的抑制中释放出来（去抑制）。去抑制模拟促进；这是眼睛中相互作用的间接影响发生在比直接抑制互连覆盖的距离更远的例子。当仅照亮两个相互作用的小眼时，对每个小眼施加的抑制（其放电频率的降低）是另一个小眼的活动程度（放电频率）的线性函数。低于某个频率（不同受体通常不同），受体不会产生抑制作用。高于该阈值，一个受体的抑制随着另一个受体的放电频率的增加而增加的速率是恒定的，并且可以至少高达在一个受体中每个由另一个受体释放的脉冲抑制0.2个脉冲。对于给定的一对相互作用受体，两个作用方向的抑制系数并不总是相同。两个相互抑制的受体单元对稳定照明的响应由两个联立线性方程定量描述，这两个方程简明地表达了上述所有特征。可以扩展这些方程并补充它们的数量以描述两个以上相互作用元件的响应。
The inhibition that is exerted mutually among the receptor units (ommatidia) in the lateral eye of Limulus has been analyzed by recording oscillographically the discharge of nerve impulses in single optic nerve fibers. The discharges from two ommatidia were recorded simultaneously by connecting the bundles containing their optic nerve fibers to separate amplifiers and recording systems. Ommatidia were chosen that were separated by no more than a few millimeters in the eye; they were illuminated independently by separate optical systems. The frequency of the maintained discharge of impulses from each of two ommatidia illuminated steadily is lower when both are illuminated together than when each is illuminated by itself. When only two ommatidia are illuminated, the magnitude of the inhibition of each one depends only on the degree of activity of the other; the activity of each, in turn, is the resultant of the excitation from its respective light stimulus and the inhibition exerted on it by the other. When additional receptors are illuminated in the vicinity of an interacting pair too far from one ommatidium to affect it directly, but near enough to the second to inhibit it, the frequency of discharge of the first increases as it is partially released from the inhibition exerted on it by the second (disinhibition). Disinhibition simulates facilitation; it is an example of indirect effects of interaction taking place over greater distances in the eye than are covered by direct inhibitory interconnections. When only two interacting ommatidia are illuminated, the inhibition exerted on each (decrease of its frequency of discharge) is a linear function of the degree of activity (frequency of discharge) of the other. Below a certain frequency (often different for different receptors) no inhibition is exerted by a receptor. Above this threshold, the rate of increase of inhibition of one receptor with increasing frequency of discharge of the other is constant, and may be at least as high as 0.2 impulse inhibited in one receptor per impulse discharged by the other. For a given pair of interacting receptors, the inhibitory coefficients are not always the same in the two directions of action. The responses to steady illumination of two receptor units that inhibit each other mutually are described quantitatively by two simultaneous linear equations that express concisely all the features discussed above. These equations may be extended and their number supplemented to describe the responses of more than two interacting elements.
DOI：
10.1085/jgp.39.5.651
发表时间：
1956-05-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
HARTLINE HK;WAGNER HG;RATLIFF F
通讯作者：
RATLIFF F