Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes.
Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes.
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DOI：
10.1002/epi4.12051
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发表时间：
2017-06
期刊：
影响因子：
3
通讯作者：
Pal DK
中科院分区：
文献类型：
--
作者：
McGinnity CJ;Smith AB;Yaakub SN;Weidenbach Gerbase S;Gammerman A;Tyson AL;Bell TK;Elmasri M;Barker GJ;Richardson MP;Pal DK
良性癫痫伴中央颞区棘波（BECTS，也称为罗兰癫痫）是一种常见的癫痫综合征，与识字和语言障碍有关。该综合征的神经机制尚不清楚。本研究的主要目的是检验BECTS儿童语言网络内的功能连接性降低的假设。我们还检验了BECTS儿童的兄弟姐妹有类似异常的假设。回波平面磁共振（MR）成像数据采集自25名儿童BECTS，12名同胞，20名健康对照，在休息。经过预处理，特别注意扫描内运动，平均信号提取90个区域的兴趣。稀疏的，无向图是从邻接矩阵构成的斯皮尔曼的秩相关系数。比较各组之间的全局和节点图指标以及子网络和成对连接。两组之间的图形指标无显著差异。与对照组相比，BECTS儿童在四节点子网络内的功能连接性降低，该子网络包括左额下回、左上级回、左缘上回和右顶叶下叶（p = 0.04）。在兄弟姐妹中也观察到类似但不显著的下降。BECTS组在五节点、五边缘额叶子网络内的连接性显著增加。研究结果进一步证明了BECTS儿童言语处理、语言和阅读的关键介质之间的功能连接性降低。我们假设这些减少反映了语言网络的延迟偏侧化，并导致特定的认知障碍。
Benign epilepsy with centrotemporal spikes (BECTS, also known as Rolandic epilepsy) is a common epilepsy syndrome that is associated with literacy and language impairments. The neural mechanisms of the syndrome are not known. The primary objective of this study was to test the hypothesis that functional connectivity within the language network is decreased in children with BECTS. We also tested the hypothesis that siblings of children with BECTS have similar abnormalities. Echo planar magnetic resonance (MR) imaging data were acquired from 25 children with BECTS, 12 siblings, and 20 healthy controls, at rest. After preprocessing with particular attention to intrascan motion, the mean signal was extracted from each of 90 regions of interest. Sparse, undirected graphs were constructed from adjacency matrices consisting of Spearman's rank correlation coefficients. Global and nodal graph metrics and subnetwork and pairwise connectivity were compared between groups. There were no significant differences in graph metrics between groups. Children with BECTS had decreased functional connectivity relative to controls within a four‐node subnetwork, which consisted of the left inferior frontal gyrus, the left superior frontal gyrus, the left supramarginal gyrus, and the right inferior parietal lobe (p = 0.04). A similar but nonsignificant decrease was also observed for the siblings. The BECTS groups had significant increases in connectivity within a five‐node, five‐edge frontal subnetwork. The results provide further evidence of decreased functional connectivity between key mediators of speech processing, language, and reading in children with BECTS. We hypothesize that these decreases reflect delayed lateralization of the language network and contribute to specific cognitive impairments.