Loss of STAT2 may be dangerous in a world filled with viruses.
Loss of STAT2 may be dangerous in a world filled with viruses.
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DOI：
10.1172/jci170886
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发表时间：
2023-06-15
影响因子：
15.9
通讯作者：
Jordan, Michael B.
中科院分区：
文献类型：
--
作者：
Jordan, Michael B.
I型干扰素是一类细胞因子，通过单一受体和信号机制发出信号，最初被命名为干扰病毒复制的能力。虽然II型干扰素(干扰素-γ)主要预防细胞内细菌和原生动物，但I型干扰素主要预防病毒感染。人类与生俱来的免疫错误已经证明了这一点，并随着越来越清楚地表明其临床意义。在本期的JCI中，Bucciol，Moens等人。报告迄今为止最大的一组STAT2缺乏的患者，STAT2是I型干扰素信号转导的重要蛋白质。STAT2缺失的个体表现出病毒易感性和炎症并发症的临床表型，其中许多仍然鲜为人知。这些发现进一步说明了I型IFN在宿主防御病毒中发挥的非常特殊和关键的作用。
Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere with viral replication. While type II IFN (IFN-γ) largely protects against intracellular bacteria and protozoa, type I IFNs largely protect from viral infections. Inborn errors of immunity in humans have demonstrated this point and its clinical relevance with increasing clarity. In this issue of the JCI, Bucciol, Moens, et al. report the largest series of patients to date with deficiency of STAT2, an important protein for type I IFN signaling. Individuals with STAT2 loss demonstrated a clinical phenotype of viral susceptibility and inflammatory complications, many of which remain poorly understood. These findings further illustrate the very specific and critical role that type I IFNs play in host defense against viruses.