High Ki67 expression is an independent good prognostic marker in colorectal cancer
High Ki67 expression is an independent good prognostic marker in colorectal cancer
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DOI：
10.1136/jclinpath-2015-202985
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发表时间：
2016-03-01
影响因子：
3.4
通讯作者：
Marx, Andreas Holger
中科院分区：
文献类型：
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作者：
Melling, Nathaniel;Kowitz, Charlotte Marie;Marx, Andreas Holger
目的探讨Ki 67在结直肠癌（CRC）中的表达及其与预后的关系。结果在1653例可解释的CRC中，Ki 67 LI低表达者占26.3%，中表达者占56.7%，高表达者占17.0%。Ki 67高表达与肿瘤低分期相关（p
Aims To correlate Ki67 expression with outcome in colorectal cancer (CRC).Methods Ki67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.Results Ki67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p