Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease
Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease
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DOI：
10.1136/jnnp.2007.141853
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发表时间：
2009-04-01
影响因子：
11
通讯作者：
Fregni, F.
中科院分区：
文献类型：
--
作者：
Boggio, P. S.;Khoury, L. P.;Fregni, F.
几项研究报告称，经颅直流电刺激（tDCS），一种非侵入性的神经调节方法，增强了健康和帕金森病受试者工作记忆的某些方面。本研究旨在探讨阳极tDCS对阿尔茨海默病（AD）患者再认记忆、工作记忆和选择性注意的影响。十名诊断为AD的患者接受了三次阳极tDCS（左背外侧前额叶皮质、左颞叶皮质和假刺激），强度为2 mA，持续30分钟。以随机顺序在不同日期进行。在刺激期间评估以下测试：Stroop、数字广度和视觉识别记忆任务（VRM）。结果显示，刺激条件对VRM有显著影响（p=0.0085），事后分析显示，与假刺激相比，颞叶（p=0.01）和前额叶（p=0.01）tDCS后改善。有没有显着的变化，注意指标Stroop任务的表现。就目前所知，这是第一次试验表明tDCS可以增强识别记忆的一个组成部分。讨论了潜在的作用机制以及这些结果的影响。
Several studies have reported that transcranial direct current stimulation (tDCS), a non-invasive method of neuromodulation, enhances some aspects of working memory in healthy and Parkinson disease subjects. The aim of this study was to investigate the impact of anodal tDCS on recognition memory, working memory and selective attention in Alzheimer disease (AD). Ten patients with diagnosis of AD received three sessions of anodal tDCS (left dorsolateral prefrontal cortex, left temporal cortex and sham stimulation) with an intensity of 2 mA for 30 min. Sessions were performed in different days in a randomised order. The following tests were assessed during stimulation: Stroop, Digit Span and a Visual Recognition Memory task (VRM). The results showed a significant effect of stimulation condition on VRM (p=0.0085), and post hoc analysis showed an improvement after temporal (p=0.01) and prefrontal (p=0.01) tDCS as compared with sham stimulation. There were no significant changes in attention as indexed by Stroop task performance. As far as is known, this is the first trial showing that tDCS can enhance a component of recognition memory. The potential mechanisms of action and the implications of these results are discussed.