Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men
Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men
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DOI：
10.1046/j.1365-2826.2003.01069.x
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发表时间：
2003-09-01
影响因子：
3.2
通讯作者：
Mantzoros, CS
中科院分区：
文献类型：
--
作者：
Mullington, JM;Chan, JL;Mantzoros, CS
本研究的目的是调查睡眠不足对循环瘦素水平的昼夜节律的影响。10名健康男性用前臂留置导管每隔90分钟采血共120h，其中持续性失眠88h。瘦素的昼夜波幅在完全睡眠剥夺时降低，在恢复睡眠时恢复正常。这一发现提供了睡眠影响夜间瘦素谱的证据，并可能有助于理解睡眠在代谢调节中的作用以及肥胖和夜间进食综合征的病因。
The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90-min intervals for a total of 120 h, which included 88 h of sustained sleeplessness, in 10 healthy men. The diurnal amplitude of leptin was reduced during total sleep deprivation and returned toward normal during the period of recovery sleep. This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome.