TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
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DOI：
10.3945/ajcn.2008.27058
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发表时间：
2009-04-01
影响因子：
7.1
通讯作者：
Hu, Frank B.
中科院分区：
文献类型：
--
作者：
Cornelis, Marilyn C.;Qi, Lu;Hu, Frank B.
背景：TCF7L2是迄今为止发现的最强的2型糖尿病（T2D）基因座，有证据表明它在胰岛素的合成、加工和分泌中起重要作用。增加胰岛素需求的饮食因素可能会增加与TCF7L2变异相关的T2D风险。目的：目的是确定与TCF7L2相关的T2D风险是否受到饮食中血糖负荷（GL）、血糖指数（GI）、谷物纤维含量和总碳水化合物含量的影响。设计：来自护士健康研究的T2D病例（n = 1140）和对照组（n = 1915）对TCF7L2 （rs12255372）进行基因分型。膳食摄入量通过半定量食物频率问卷进行评估。结果：T2D与TCF7L2基因型相关的比值比（ORs）在GL高低层（P = 0.03）和GI高低层（P = 0.05）之间存在显著差异。与GG基因型比较，在GL和GI最高分位个体中，T2D与TT基因型相关的多变量校正ORs （95% CI）分别为2.71（1.64,4.46）和2.69（1.64,4.43）。GL和GI最低分等个体对应的or （95% ci）分别为1.66（0.95、2.88）和1.82（1.11、3.01）。与TCF7L2单核苷酸多态性相关的T2D风险与谷物纤维或碳水化合物摄入量没有显著差异。结论：碳水化合物质量和数量改变T2D风险与TCF7L2相关，这表明在胰岛素需求增加的情况下，TCF7L2变异导致的风险变化被放大。m J . clinn [2009]；89: 1256 - 62。
Background: TCF7L2 is the strongest type 2 diabetes (T2D) locus identified to date, and evidence suggests it plays an important role in insulin synthesis, processing, and secretion. Dietary factors that increase the insulin demand might enhance the risk of T2D associated with TCF7L2 variants.Objective: The objective was to determine whether the risk of T2D associated with TCF7L2 is modified by the glycemic load (GL), glycemic index (GI), cereal fiber content, and total carbohydrate content of the diet.Design: T2D cases (n = 1140) and controls (n 1915) from the Nurses' Health Study were genotyped for TCF7L2 (rs12255372). Dietary intake was assessed with a semiquantitative food-frequency questionnaire.Results: Significant differences in odds ratios (ORs) of T2D associated with the TCF7L2 genotype between high and low strata of GL (P = 0.03) and GI (P = 0.05) were suggested. Compared with the GG genotype, multivariate-adjusted ORs (95% CI) of T2D associated with the TT genotype were 2.71 (1.64, 4.46) and 2.69 (1.64, 4.43) among individuals in the highest tertile of GL and GI, respectively. Corresponding ORs (95% CIs) among individuals in the lowest tertiles of GL and GI were 1.66 (0.95, 2.88) and 1.82 (1.11, 3.01). The risk of T2D associated with the TCF7L2 single nucleotide polymorphism did not significantly differ by cereal fiber or carbohydrate intake.Conclusion: Carbohydrate quality and quantity modified risk of T2D associated with TCF7L2, which suggests that changes in risk attributable to the TCF7L2 variant are magnified under conditions of increased insulin demand. Am J Clin Nutr 2009; 89: 1256-62.