A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants
A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants
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DOI：
10.1038/s41390-019-0517-2
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发表时间：
2020-07-01
影响因子：
3.6
通讯作者：
Polin, Richard A.
中科院分区：
文献类型：
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作者：
Wynn, James L.;Polin, Richard A.
背景：目前尚缺乏适用于新生儿器官功能障碍的可操作性定义来预测感染环境下的死亡率。我们确定了客观的电子健康记录(EHR)自动化新生儿序贯器官衰竭评估(NSOFA)评分在预测早产儿、极低出生体重(VLBW)婴儿迟发性败血症(LOS)死亡率方面的有效性。方法对2012~2016年间收治的细菌性早产儿极低出生体重儿进行单中心回顾性研究。在脓毒症评估周围的多个时间点，对LOS患者进行nSOFA评分。结果存活患者与死亡患者在评估时及评估后各时间点的nSOFA评分均有差异。在nSOFA评分为4的患者中，与评分为4的患者相比，在评估时(13%对67%，p<；0.001)、+6小时(15%对，p=0.002)和+12小时(7%对71%，p<；0.001)的死亡率更高。
Background An operational definition of organ dysfunction applicable to neonates that predicts mortality in the setting of infection is lacking. We determined the utility of an objective, electronic health record (EHR)-automated, neonatal sequential organ failure assessment (nSOFA) score to predict mortality from late-onset sepsis (LOS) in premature, very low birth weight (VLBW) infants. Methods Retrospective, single-center study of bacteremic preterm VLBW newborns admitted between 2012 and 2016. nSOFA scores were derived for patients with LOS at multiple time points surrounding the sepsis evaluation. Results nSOFA scores at evaluation and at all points measured after evaluation were different between survivors and non-survivors. Among patients with an nSOFA score of >4, mortality was higher at evaluation (13% vs 67%,p < 0.001), +6 h (15% vs 64%,p = 0.002), and +12 h (7% vs 71%,p < 0.001) as compared to patients with a score of