IDENTIFICATION OF HUMAN AND RODENT THYMIC EPITHELIUM USING TETANUS TOXIN AND MONOCLONAL-ANTIBODY A2B5
IDENTIFICATION OF HUMAN AND RODENT THYMIC EPITHELIUM USING TETANUS TOXIN AND MONOCLONAL-ANTIBODY A2B5
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DOI：
10.1172/jci110755
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发表时间：
1983-01-01
影响因子：
15.9
通讯作者：
EISENBARTH, GS
中科院分区：
文献类型：
--
作者：
HAYNES, BF;SHIMIZU, K;EISENBARTH, GS
使用与GQ神经节苷脂结合的单克隆抗体（A2 B5）以及与GD和GT神经节苷脂结合的破伤风毒素，已经鉴定了人和啮齿动物胸腺上皮细胞的不同区域。胸腺的淋巴成分不结合A2 B5或破伤风毒素。A2 B5和破伤风毒素结合细胞形成遍及胸腺被膜下皮质和胸腺髓质的胸腺上皮细胞网络，并含有胸腺生成素和胸腺素α- 1.
Using a monoclonal antibody (A2B5), which binds to GQ ganglioside, as well as tetanus toxin, which binds to GD and GT gangliosides, distinct regions of human and rodent thymic epithelial cells have been identified. The lymphoid elements of the thymus do not bind A2B5 or tetanus toxin. The A2B5 and tetanus toxin-binding cells form a network of thymic epithelial cells throughout the thymic subcapsular cortex and thymic medulla, and contain thymopoietin and thymosin .alpha.-1.