Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex
Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex
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DOI：
10.1073/pnas.93.11.5584
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发表时间：
1996-05-28
影响因子：
11.1
通讯作者：
OLeary, DDM
中科院分区：
文献类型：
--
作者：
Fox, K;Schlaggar, BL;OLeary, DDM
在发育中的猫或猴视觉皮层中，丘脑皮层输入分离成眼睛特定的条纹，这是通过干扰或取消视觉通路中的神经活动来防止的。这些发现表明，视皮层功能组织的正常发育依赖于正常的神经活动模式。将这一结论推广到其他感觉皮层受到了质疑，因为在发育中的啮齿动物初级躯体感觉皮层（S1）中，丘脑皮层传入神经分离成躯体定位的桶形模式，活动阻滞不能阻止这种分离。我们表明，在桶发育的关键时期，大鼠S1中N-甲基-D-天冬氨酸（NMDA）和非NMDA谷氨酸受体的暂时阻断会破坏丘脑皮质连接性和柱状组织的地形细化。这些影响在封锁失效后很久才明显，因此可能是永久性的。我们的研究结果表明，神经活动，特别是突触后皮层神经元的激活有一个突出的作用，在建立初级感觉地图在S1，以及地形组织的高阶突触连接。
The segregation of thalamocortical inputs into eye-specific stripes in the developing cat or monkey visual cortex is prevented by manipulations that perturb or abolish neural activity in the visual pathway. Such findings show that proper development of the functional organization of visual cortex is dependent on normal patterns of neural activity. The generalization of this conclusion to other sensory cortices has been questioned by findings that the segregation of thalamocortical afferents into a somatotopic barrel pattern in developing rodent primary somatosensory cortex (S1) is not prevented by activity blockade. We show that a temporary block of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in rat S1 during the critical period for barrel development disrupts the topographic refinement of thalamocortical connectivity and columnar organization. These effects are evident well after the blockade is ineffective and thus may be permanent. Our findings show that neural activity and specifically the activation of postsynaptic cortical neurons has a prominent role in establishing the primary sensory map in S1, as well as the topographic organization of higher order synaptic connections.