Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule
Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule
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DOI：
10.1016/j.lungcan.2007.08.021
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发表时间：
2008-04-01
期刊：
影响因子：
5.3
通讯作者：
Kohno, Shigeru
中科院分区：
文献类型：
--
作者：
Nakano, Hirofumi;Soda, Hiroshi;Kohno, Shigeru
有人提出，从非典型腺瘤样增生（AAH）到细支气管肺泡癌（BAC）再到浸润性肺腺癌，发生逐步进展。然而，潜在的分子机制尚未确定。我们报告一例混合型肺腺癌患者，其乳头状亚型、腺泡亚型以及周围AAH和BAC区域存在不同的EGFR突变。EGFR突变可能在肿瘤进展过程中积累，并导致肿瘤内EGFR突变的异质性。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
It has been proposed that stepwise progression occurs from atypical adenomatous hyperplasia (AAH) through bronchioloalveolar carcinoma (BAC) to invasive lung adenocarcinoma. However, the underlying molecular mechanisms have not been identified. We report a patient with a mixed adenocarcinoma of the lung that had different EGFR mutations in the papillary subtype, the acinar subtype, and the surrounding AAH and BAC areas. EGFR mutations may accumulate during tumor progression and lead to heterogeneity of EGFR mutations within the tumor. (C) 2007 Elsevier Ireland Ltd. All rights reserved.