Montmorency Cherries Reduce the Oxidative Stress and Inflammatory Responses to Repeated Days High-Intensity Stochastic Cycling
Montmorency Cherries Reduce the Oxidative Stress and Inflammatory Responses to Repeated Days High-Intensity Stochastic Cycling
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DOI：
10.3390/nu6020829
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发表时间：
2014-02-01
期刊：
影响因子：
5.9
通讯作者：
Howatson, Glyn
中科院分区：
文献类型：
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作者：
Bell, Phillip G.;Walshe, Ian H.;Howatson, Glyn
通过3天的模拟公路自行车赛，研究了蒙莫伦西酸樱桃浓缩液(MC)对氧化应激、炎症和肌肉损伤的生理指标的影响。将16名训练有素的自行车手分成两组，分别服用MC或安慰剂30m L，每日2次，连续7d。分别于第5、6、7天进行109min的模拟高强度公路骑行试验。分别于试验前、试验前、试验后第5、6、7天采血检测氧化应激和炎症反应，检测血清过氧化脂质(LOOH)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、白介素8(IL-8)、白介素1-β(IL-1-β)、高敏C反应蛋白(HsCRP)和肌酸激酶(CK)。MC组的LOOH(p<；0.01)、IL-6(p<；0.05)和hsCRP(p<；0.05)对试验的反应低于聚乳酸。其他标记均未发现群体效应或互作效应。氧化和炎症反应的减弱表明MC可能有效地对抗运动后可能导致细胞破坏的氧化和炎症级联反应。此外，我们还演示了MC在重复几天的自行车比赛中的直接应用，以及可以想象的其他需要背靠背表演的体育场景。
This investigation examined the impact of Montmorency tart cherry concentrate (MC) on physiological indices of oxidative stress, inflammation and muscle damage across 3 days simulated road cycle racing. Trained cyclists (n = 16) were divided into equal groups and consumed 30 mL of MC or placebo (PLA), twice per day for seven consecutive days. A simulated, high-intensity, stochastic road cycling trial, lasting 109 min, was completed on days 5, 6 and 7. Oxidative stress and inflammation were measured from blood samples collected at baseline and immediately pre- and post-trial on days 5, 6 and 7. Analyses for lipid hydroperoxides (LOOH), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), interleukin-1-beta (IL-1-beta), high-sensitivity C-reactive protein (hsCRP) and creatine kinase (CK) were conducted. LOOH (p < 0.01), IL-6 (p < 0.05) and hsCRP (p < 0.05) responses to trials were lower in the MC group versus PLA. No group or interaction effects were found for the other markers. The attenuated oxidative and inflammatory responses suggest MC may be efficacious in combating post-exercise oxidative and inflammatory cascades that can contribute to cellular disruption. Additionally, we demonstrate direct application for MC in repeated days cycling and conceivably other sporting scenario's where back-to-back performances are required.