Antimicrobial effects of silver nanoparticles
Antimicrobial effects of silver nanoparticles
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DOI：
10.1016/j.nano.2006.12.001
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发表时间：
2007-03-01
影响因子：
5.4
通讯作者：
Cho, Myung-Haing
中科院分区：
文献类型：
--
作者：
Kim, Jun Sung;Kuk, Eunye;Cho, Myung-Haing
银离子及其盐的抗菌作用已为人们所熟知，但纳米银颗粒对微生物的影响及抗菌机理尚未完全阐明。制备了稳定的银纳米粒子，并通过粒子表征仪和透射电镜研究了其形状和尺寸分布。研究了银纳米粒子对酵母菌、大肠杆菌和金黄色葡萄球菌的抗菌活性。在这些试验中，使用Muller欣顿琼脂平板，并在液体系统中补充各种浓度的Ag纳米颗粒。结果表明，酵母和E.在低浓度下，纳米银对大肠杆菌的生长抑制作用明显，而对S.金黄色葡萄球菌轻度。利用电子自旋共振技术研究了银纳米粒子抑制微生物生长的自由基生成效应。这些结果表明，银纳米粒子可用作各种微生物的有效生长抑制剂，使其适用于各种医疗器械和抗菌控制系统。(c)2007爱思唯尔公司All rights reserved.
The antimicrobial effects of silver (Ag) ion or salts are well known, but the effects of Ag nanoparticles on microorganisms and antimicrobial mechanism have not been revealed clearly. Stable Ag nanoparticles were prepared and their shape and size distribution characterized by particle characterizer and transmission electron microscopic study. The antimicrobial activity of Ag nanoparticles was investigated against yeast, Escherichia coli, and Staphylococcus aureus. In these tests, Muller Hinton agar plates were used and Ag nanoparticles of various concentrations were supplemented in liquid systems. As results, yeast and E. coli were inhibited at the low concentration of Ag nanoparticles, whereas the growth-inhibitory effects on S. aureus were mild. The free-radical generation effect of Ag nanoparticles on microbial growth inhibition was investigated by electron spin resonance spectroscopy. These results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems. (c) 2007 Elsevier Inc. All rights reserved.