Role of soluble adenylyl cyclase in mitochondria.
Role of soluble adenylyl cyclase in mitochondria.
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DOI:
10.1016/j.bbadis.2014.05.035
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发表时间:
2014-12
影响因子:
6.2
通讯作者:
Manfredi, Giovanni
中科院分区:
文献类型:
--
作者:
Valsecchi, Federica;Konrad, Csaba;Manfredi, Giovanni
The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO3−) and calcium (Ca2+) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism.
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影响因子:
4.4
作者:
Boja, Emily S.;Phillips, Darci;French, Stephanie A.;Harris, Robert A.;Balaban, Robert S.
通讯作者:
Balaban, Robert S.
影响因子:
29
作者:
Di Benedetto, Giulietta;Scalzotto, Elisa;Pozzan, Tullio
通讯作者:
Pozzan, Tullio
影响因子:
7.4
作者:
De Rasmo, Domenico;Signorile, Anna;Papa, Sergio
通讯作者:
Papa, Sergio
影响因子:
--
作者:
Depry, Charlene;Allen, Michael D.;Zhang, Jin
通讯作者:
Zhang, Jin
DOI:
10.1083/jcb.200204081
发表时间:
2002-08-19
期刊:
The Journal of cell biology
影响因子:
--
作者:
Alto NM;Soderling J;Scott JD
通讯作者:
Scott JD