Role of soluble adenylyl cyclase in mitochondria.

Role of soluble adenylyl cyclase in mitochondria.
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DOI:
10.1016/j.bbadis.2014.05.035
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发表时间:
2014-12
影响因子:
6.2
通讯作者:
Manfredi, Giovanni
Manfredi, Giovanni
中科院分区:
生物学2区
文献类型:
--
作者:
Valsecchi, Federica;Konrad, Csaba;Manfredi, Giovanni

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The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO3−) and calcium (Ca2+) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism.
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