Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case?control study
Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case?control study
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尿 N1,N12-二乙酰精胺作为儿科癌症生物标志物：病例对照研究
DOI：
10.1007/s00383-021-04987-y
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发表时间：
2021
影响因子：
1.8
通讯作者：
Kawakita Masao
中科院分区：
文献类型：
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作者：
Yokota Kazuki;Hinoki Akinari;Hiramatsu Kyoko;Amano Hizuru;Kawamura Machiko;Kuwatsuka Yachiyo;Tainaka Takahisa;Shirota Chiyoe;Sumida Wataru;Makita Satoshi;Okamoto Masamune;Takimoto Aitaro;Yasui Akihiro;Nakagawa Yoichi;Uchida Hiroo;Kawakita Masao
目的微创检查对儿科患者尤为重要。尽管尿 N1,N12-二乙酰精胺 (DiAcSpm) 作为肿瘤标志物 (TM) 在许多类型的成人癌症中的重要性已被报道，但其在儿科癌症中的用途尚未报道。这可能是由于尿 DiAcSpm 水平随年龄变化而变化。本研究旨在测量健康个体尿液中 DiAcSpm 的正常水平，并研究其作为 TM 在儿童癌症中的有用性。方法收集患有和未患有癌症的儿科患者的尿液样本。测量尿DiAcSpm水平，并比较各值。结果共有32名癌症患者和405名对照者参加了该研究。 32 名患者中，13 名患有神经母细胞瘤，9 名患有恶性淋巴瘤 (ML)，10 名患有白血病。对照组中，年龄较小者尤其是婴儿尿DiAcSpm值波动明显；与此同时，这些价值观在大约 10 岁及以上的人群中趋于一致。 DiAcSpm 的敏感性在三种类型的癌症中存在显着差异：神经母细胞瘤 (30.8%)、ML (77.8%) 和白血病 (40%)。 结论 尿 DiAcSpm 值对于 ML 的筛查和随访是有用的 TM。
PurposeMinimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer.MethodsUrinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared.ResultsA total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%).ConclusionThe urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.