Induction of cellular and humoral immunity after aerosol or subcutaneous administration of Edmonston-Zagreb measles vaccine as a primary dose to 12-month-old children.
Induction of cellular and humoral immunity after aerosol or subcutaneous administration of Edmonston-Zagreb measles vaccine as a primary dose to 12-month-old children.
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对 12 个月大的儿童进行气雾剂或皮下注射埃德蒙斯顿-萨格勒布麻疹疫苗作为初级剂量后诱导细胞和体液免疫。
DOI：
10.1086/380565
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Valdespino-Gómez,JoséLuis
中科院分区：
文献类型：
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作者：
Wong-Chew,RosaMaría;Islas-Romero,Rocío;García-García,MariadeLourdes;Beeler,JudyA;Audet,Susette;Santos-Preciado,JoseIgnacio;Gans,Hayley;Lew-Yasukawa,Linda;Maldonado,YvonneA;Arvin,AnnM;Valdespino-Gómez,JoséLuis
婴儿用埃德蒙斯顿-萨格勒布麻疹疫苗气雾剂(103.6个空斑形成单位[pfu]/剂)或皮下(104.27pfu/剂)接种。在接种气雾剂疫苗的儿童中，72%的儿童出现了刺激指数为⩾3的麻疹特异性T细胞增殖反应，而皮下注射疫苗的儿童中这一比例为87%(P= .06)。雾化疫苗接种后血清阳转率为90%，皮下注射疫苗后为100%(P=0.01)，麻疹几何平均滴度分别为237毫国际单位(95%可信区间，146~385mIU)和487mIU(95%可信区间，390~609mIU)(P=0.01)。麻疹特异性T和B细胞在气雾剂接种后的反应比sc疫苗接种后更弱，这表明需要使用更高的气雾剂剂量来获得最佳的免疫原性。
Infants were immunized by aerosol (103.6plaque-forming units [pfu]/dose) or subcutaneous (sc) (104.27pfu/dose) administration of Edmonston-Zagreb measles vaccine. Measles-specific T cell proliferative responses with a stimulation index of ⩾3 developed in 72% of children given aerosol-administered vaccine, compared with 87% given sc-administered vaccine (P= .06). Seroconversion rates were 90% after aerosol-administered vaccine and 100% after sc-administered vaccine (P=.01), and measles geometric mean titers were 237 milli–international units (mIU) (95% confidence interval [CI], 146–385 mIU) and 487 mIU (95% CI, 390–609 mIU) in each group, respectively (P=.01). Measles-specific T and B cell responses were weaker after aerosol than after sc vaccination, indicating a need to use a higher aerosol dose to achieve optimal immunogenicity