The disease intersection of susceptibility and exposure: Chemical exposures and neurodegenerative disease risk
The disease intersection of susceptibility and exposure: Chemical exposures and neurodegenerative disease risk
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DOI：
10.1016/j.jalz.2014.04.014
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发表时间：
2014-06-01
影响因子：
14
通讯作者：
Grate, Stephen J.
中科院分区：
文献类型：
--
作者：
Tanner, Caroline M.;Goldman, Samuel M.;Grate, Stephen J.
阿尔茨海默病、帕金森病和运动神经元病是最常见的晚年神经退行性疾病，在大多数情况下被认为具有复杂的病因。这些疾病的共同特征包括隐匿性发作、蛋白质聚集和选择性神经元变性的病理学发现以及由此产生的特征性临床综合征。美国老年人的数量，包括老年退伍军人，正在增加。对神经退行性疾病的原因和预防干预的调查越来越重要。最近的流行病学和实验室研究表明，诊断前数年或数十年的暴露可能引发最终导致神经退行性疾病的过程。如果这是正确的，预防措施可能需要在中年或更早。这篇文章将重点关注与服兵役有关的假定危险因素。爱思唯尔公司出版代表老年痴呆症协会
Alzheimer's disease, Parkinson's disease, and motor neuron disease, the most common of the late-life neurodegenerative disorders, are in most cases thought to have complex etiologies. Common features among these disorders include insidious onset, pathological findings of protein aggregates and selected neuronal degeneration, and resulting characteristic clinical syndromes. The number of elders in the United States, including aging veterans, is increasing. Investigation of causes and preventive interventions for neurodegenerative disorders is increasingly relevant. Recent epidemiological and laboratory studies suggest that exposures years or decades before diagnosis can trigger the processes that ultimately result in a neurodegenerative disease. If this is correct, preventive measures may be needed in midlife or earlier. This article will focus on putative risk factors relevant to military service. Published by Elsevier Inc. on behalf of The Alzheimer's Association.