Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death
Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death
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DOI：
10.1126/stke.3792007pe11
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发表时间：
2007-03
期刊：
影响因子：
--
通讯作者：
B. Steinberg;S. Grinstein
中科院分区：
文献类型：
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作者：
B. Steinberg;S. Grinstein
尽管吞噬性 NADPH 氧化酶在介导细菌杀灭中的核心作用早已被人们所认识，但这种复杂的酶复合物还具有各种其他重要功能。本视角重点关注吞噬性 NADPH 氧化酶的这些未被充分认识的作用，重点介绍了最近的研究表明活性氧可引发非常规形式的细胞死亡。
Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has long been appreciated, this sophisticated enzyme complex serves various other important functions. This Perspective focuses on these underappreciated roles of phagocytic NADPH oxidase, highlighting recent work implicating reactive oxygen species in triggering an unconventional form of cell death.