Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy.
Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy.
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自组装载有 IR780 的转铁蛋白纳米颗粒作为癌症治疗的成像、靶向和 PDT/PTT 试剂
DOI：
10.1038/srep27421
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发表时间：
2016-06-06
影响因子：
4.6
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Wang K;Zhang Y;Wang J;Yuan A;Sun M;Wu J;Hu Y
光热和光动力疗法（PTT/PDT）的组合提供了比单独PDT独特的优势。然而，为了实现协同PDT/PTT效应，通常需要具有不同波长的两个激光器。近红外染料IR-780可作为光敏剂用于PTT和PDT，但其亲脂性限制了其实际应用和体内效率。在此，开发了一种基于转铁蛋白的简单多功能IR 780负载纳米平台，用于与单次NIR激光照射兼容的癌症靶向成像和光疗。自组装的转铁蛋白-IR 780纳米颗粒（Tf-IR 780 NPs）具有窄的粒径分布、良好的光稳定性和令人鼓舞的光热性能，并且在激光照射下增加了ROS的产生。静脉注射后，Tf-IR 780纳米颗粒在CT 26荷瘤小鼠中具有高的肿瘤与背景比。用Tf-IR 780 NP处理导致显著的肿瘤抑制。总的来说，Tf-IR 780纳米颗粒在癌症治疗中显示出显著的靶向和治疗诊断潜力。
Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. Near-infrared dye IR-780 could be used as photosensitizer both for PTT and PDT, but its lipophilicity limits its practical use andin vivoefficiency. Herein, a simple multifunctional IR780-loaded nanoplatform based on transferrin was developed for targeted imaging and phototherapy of cancer compatible with a single-NIR-laser irradiation. The self-assembled transferrin-IR780 nanoparticles (Tf-IR780 NPs) exhibited narrow size distribution, good photo-stability and encouraging photothermal performance with enhanced generation of ROS under laser irradiation. Following intravenous injection, Tf-IR780 NPs had a high tumor-to-background ratio in CT26 tumor-bearing mice. Treatment with Tf-IR780 NPs resulted in significant tumor suppression. Overall, the Tf-IR780 NPs show notable targeting and theranostic potential in cancer therapy.