Minimally invasive surgery for ICH evacuation followed by rosiglitazone infusion therapy increased perihematomal PPARγ expression and improved neurological outcomes in rabbits
Minimally invasive surgery for ICH evacuation followed by rosiglitazone infusion therapy increased perihematomal PPARγ expression and improved neurological outcomes in rabbits
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微创手术清除 ICH，随后进行罗格列酮输注治疗可增加兔血肿周围 PPARγ 表达并改善神经系统结果
DOI：
10.1080/01616412.2015.1105627
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Zhouping Tang
中科院分区：
文献类型：
--
作者：
Guofeng Wu;Junjie Wu;Lilkun Wang;Yu Jiao;Houguang Zhou;Zhouping Tang
目的：目的观察微创手术（MIS）清除脑内血肿（ICH）后应用罗格列酮治疗对脑组织过氧化物酶体增殖物激活受体γ（PPARγ）、血脑屏障（BBB）通透性及神经功能的影响。研究方法：将75只雄性家兔（2.8- 3.4kg）随机分为正常对照组（NC组）、模型对照组（MC组）、罗格列酮组（RSG组）、微创治疗组（MIS组）和MIS+罗格列酮组（MIS+RSG组）。除NC组外，其余各组均诱发脑出血。RSG组和MIS+RSG组血肿区注入罗格列酮。MIS组和MIS+RSG组均于造模成功后6 h行MIS引流。每组包括15只家兔，并平均分为3个亚组（每个亚组包括5只家兔，分别在第1天、第3天或第7天处死）。测定神经功能缺损评分，并取血肿周围脑组织测定过氧化物酶体增殖物激活受体γ（PPARγ）水平和血脑屏障通透性。结果如下：与NC组相比，MC组的神经功能缺损评分、血肿周围的PPARγ水平和BBB通透性均显著增加。单独进行MIS以排空ICH导致这些指数显著降低。单独使用RSG可增加PPARγ水平并减少BBB破坏。MIS+RSG组的PPARγ水平显著升高，BBB通透性和神经功能缺损评分显著降低。结论：微创手术后再行PPARγ激动剂灌注治疗，对减轻脑继发性损伤、改善神经功能更为有效。
Objectives: To observe the effects of minimally invasive surgery (MIS) for intracerebral hematoma (ICH) evacuation.followed by rosiglitazone infusion therapy on peroxisome proliferator-activated receptor-gamma (PPARγ), blood–.brain barrier (BBB) permeability, and neurological function..Methods: A total of 75 male rabbits (2.8–3.4 kg) were randomly assigned to a normal control group (NC group),.a model control group (MC group), a rosiglitazone group (RSG group), a minimally invasive treatment group (MIS.group) or a MIS combined with rosiglitazone group (MIS+RSG group). ICH was induced in all of the animals.except for those in the NC group. The rosiglitazone was infused into the hematoma area in the RSG group and.the MIS+RSG group. A MIS was performed to evacuate the ICH 6 h after the successful preparation of the ICH.model in the MIS group and the MIS+RSG group. Each group included 15 rabbits and was divided equally into.3 subgroups (each subgroup included 5 rabbits that were killed on day 1, day 3, or day 7). Neurological deficit.scores were determined, and the perihematomal brain tissue was removed to determine the PPARγ level and.BBB permeability..Results: Neurological deficit scores, perihematomal PPARγ levels, and BBB permeability were all significantly.increased in the MC group compared to the NC group. Performing the MIS alone to evacuate the ICH resulted in.a marked decrease in these indices. The RSG used alone increased PPARγ levels and decreased BBB disruption..The MIS+RSG group displayed a marked increase in PPARγ levels and a more significant decrease in BBB.permeability and neurological deficit scores..Conclusions: Performing MIS followed by PPARγ agonist infusion therapy is more efficacious for reducing.secondary damage to the brain and improving neurological function.
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DOI：
--
发表时间：
2003
期刊：
--
影响因子：
--
作者：
O. P. M. Teernstra;S. M. A. A. Evers-S.-M.-A.-A.-Evers-2263642757;J. Lodder;P. Leffers;C. Franke;G. Blaauw
通讯作者：
O. P. M. Teernstra;S. M. A. A. Evers-S.-M.-A.-A.-Evers-2263642757;J. Lodder;P. Leffers;C. Franke;G. Blaauw
罗格列酮减轻大鼠短暂局灶性缺血后高血糖增强的出血转化
影响因子：
3.3
作者：
Huang, H. G.;Sun, J. Z.;Wen, S. Q.;Lou, M.
通讯作者：
Lou, M.
DOI：
10.1016/b978-0-323-43140-8.00022-6
发表时间：
2012-09
期刊：
Neuromethods
影响因子：
--
作者：
L. Beslać-Bumbaširević;Višnja Pađen;Dejana R. Jovanovic;Maja Stefanović-Budimkić
通讯作者：
L. Beslać-Bumbaširević;Višnja Pađen;Dejana R. Jovanovic;Maja Stefanović-Budimkić
DOI：
10.1007/978-3-7091-1434-6_53
发表时间：
2013-01-01
期刊：
Acta neurochirurgica. Supplement
影响因子：
--
作者：
Takeuchi, Satoru;Takasato, Yoshio;Shima, Katsuji
通讯作者：
Shima, Katsuji
影响因子：
8.3
作者：
Zhao, Xiurong;Grotta, James;Aronowski, Jaroslaw
通讯作者：
Aronowski, Jaroslaw