Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
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DOI：
10.7554/elife.17023
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发表时间：
2016-07-11
期刊：
影响因子：
7.7
通讯作者：
Lohmann, Jan U.
中科院分区：
文献类型：
--
作者：
Pfeiffer, Anne;Janocha, Denis;Lohmann, Jan U.
胚胎发生的一个主要特征是干细胞系统的特化，但与大多数动物的情况相反，植物干细胞在发育的胚后阶段之前保持静止。在这里，我们剖析了光和代谢信号是如何整合，以克服干细胞休眠在拍摄顶端分生组织。我们一方面表明，光能够独立于光合作用激活干细胞诱导物WUSCHEL的表达，并且这可能涉及区域间细胞分裂素信号传导。另一方面，代谢信号通过激活雷帕霉素靶蛋白（TOR）激酶传导至分生组织。令人惊讶的是，TOR也是光信号依赖性干细胞激活所必需的。因此，TOR激酶作为光和代谢信号的中心整合者和茎尖干细胞活化的关键调节剂。
A major feature of embryogenesis is the specification of stem cell systems, but in contrast to the situation in most animals, plant stem cells remain quiescent until the postembryonic phase of development. Here, we dissect how light and metabolic signals are integrated to overcome stem cell dormancy at the shoot apical meristem. We show on the one hand that light is able to activate expression of the stem cell inducer WUSCHEL independently of photosynthesis and that this likely involves inter-regional cytokinin signaling. Metabolic signals, on the other hand, are transduced to the meristem through activation of the TARGET OF RAPAMYCIN (TOR) kinase. Surprisingly, TOR is also required for light signal dependent stem cell activation. Thus, the TOR kinase acts as a central integrator of light and metabolic signals and a key regulator of stem cell activation at the shoot apex.