Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases
Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases
复制标题
DOI：
10.1038/sj.gene.6363779
复制
发表时间：
2001-08-01
影响因子：
5
通讯作者：
Epplen, JT
中科院分区：
文献类型：
--
作者：
Klein, W;Tromm, A;Epplen, JT
Th1和Th2淋巴细胞调节失衡在炎症性肠病中起关键作用。IL-4由Th2淋巴细胞分泌，并下调Th1淋巴细胞产生的细胞因子。在白介素4和白介素4受体α基因中已经描述了功能相关的多态。最近有报道称炎症性肠病与这些基因的多态有关，这表明克罗恩病的转录水平高，信号活性增强。我们的研究包括211例克罗恩病患者，147例溃疡性结肠炎患者和446名健康对照，发现克罗恩病与IL-4基因的-590T等位基因显著相关(P=0.03)。这种等位基因导致IL-4的表达减少。这些不同发现的原因可以在假定易感等位基因与白介素4基因的等位基因连锁不平衡的背景下进行讨论。
Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine production from Th1 lymphocytes. Functionally relevant polymorphisms have been described in the interleukin-4 and the interleukin-4 receptor alpha genes. Association of inflammatory bowel diseases with these polymorphisms has been reported recently suggesting high transcription and enhanced signalling activity in Crohn's disease. Our study, comprising 211 patients with Crohn's disease, 147 patients with ulcerative colitis and 446 healthy controls revealed significant association of Crohn's disease with the -590 T allele of the interleukin-4 gene (P = 0.03). This allele entails reduced expression of IL-4. The reason for these contrasting findings may be discussed in the context of a putatively predisposing allele in linkage disequilibrium with the alleles of the interleukin-4 gene.