Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs
Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs
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DOI：
10.1016/j.jad.2011.08.013
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发表时间：
2012-01-01
影响因子：
6.6
通讯作者：
Rehavi, Moshe
中科院分区：
文献类型：
--
作者：
Bismuth-Evenzal, Yona;Gonopolsky, Yehudit;Rehavi, Moshe
背景：选择性5-羟色胺再摄取抑制剂(SSRIs)的慢性治疗可降低心血管疾病的风险和严重程度。SSRI阻断5-羟色胺转运体，从而抑制5-羟色胺(5-HT)在突触前神经元和血小板中的摄取，5-羟色胺在血小板中储存在致密的颗粒中。当5-羟色胺被激动剂释放时，它会增强损伤相关信号诱导的血小板聚集。因此，长期服用SSRIs可能会降低继发于血小板5-羟色胺储存耗竭的血小板聚集性。方法：研究包括10名DSM-IV-TR型重度抑郁症(MDD)和4名强迫症(OCD)患者和14名年龄和性别匹配的健康对照。患者接受不同SSRI的慢性药物治疗(6-108个月)。用放射免疫法测定新鲜富血小板血浆(PRP)中5-羟色胺的含量。以ADP、胶原蛋白、花生四烯酸和肾上腺素为诱导剂，在微板仪上用浊度法测定PRP中的血小板聚集。
Background: Chronic treatment with selective serotonin reuptake inhibitors (SSRIs) reduces the risk and severity of cardiovascular diseases. SSRIs block the serotonin transporter, thereby inhibiting serotonin (5-HT) uptake into presynaptic neurons as well as into platelets where 5-HT is stored in dense granules. When 5-HT is released in response to agonists it enhances platelet aggregation induced by injury-related signals. Chronic administration of SSRIs may thus reduce platelet aggregability secondary to depletion of platelets' serotonin stores.Methods: The study included ten DSM-IV-TR major depression (MDD) and four obsessive compulsive disorder (OCD) patients and fourteen healthy untreated age- and sex-matched controls. The patients were chronically medicated (6-108 months) with various SSRIs. Platelet serotonin content was assessed in fresh samples of platelet rich plasma (PRP) using radioimmunoassay. ADP, collagen, arachidonic acid and epinephrine were used as inducers of platelet aggregation measured in PRP by turbometric method in a microplate reader.Results: Lower platelet serotonin content (66%; p