Microstructural properties of white matter pathways in relation tosubsequent reading abilities in children: a longitudinal analysis
Microstructural properties of white matter pathways in relation tosubsequent reading abilities in children: a longitudinal analysis
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DOI：
10.1007/s00429-018-1813-z
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发表时间：
2019-03-01
影响因子：
3.1
通讯作者：
Feldman, Heidi M.
中科院分区：
文献类型：
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作者：
Borchers, Lauren R.;Bruckert, Lisa;Feldman, Heidi M.
白质通路的微观结构特性与儿童并发阅读能力有关。在这项纵向研究中，我们询问在开始学习阅读时白质通路的特性是否与老年阅读能力有关。具有广泛阅读能力的儿童（N=37）在6岁时完成了语言和语音意识以及扩散MRI的标准化测量。从阅读相关通路中提取平均束分数各向异性（FA）。在8岁时，同样的孩子使用标准化阅读测试进行重新评估。使用线性回归，我们检查了6岁时的通道fa对8岁阅读结果的贡献，超出了已知的人口统计学和识字前的阅读预测因素。考虑到性别和家族史的阅读延迟，左弓状束fa、左右上纵束（SLF）和左小脑下蒂（ICP）对阅读结果有独特的贡献。添加识字前技能后，左、右SLF和左ICP的行道fa对阅读结果有独特的贡献。因此，小脑和双侧皮质通路代表了一个与后续阅读能力相关的网络。早期白质特性可能与预测阅读或影响阅读发展的其他神经心理功能有关，独立于阅读相关能力。在学习阅读的早期阶段，通道FA可以作为后来阅读能力的生物标志物。
Microstructural properties of white matter pathways are associated with concurrent reading abilities in children. In this longitudinal study, we asked whether properties of white matter pathways at the onset of learning to read would be associated with reading abilities at older ages. Children (N=37) with a wide range of reading abilities completed standardized measures of language and phonological awareness and diffusion MRI at age 6years. Mean tract-fractional anisotropy (FA) was extracted from reading-related pathways. At age 8, the same children were re-assessed using a standardized reading measure. Using linear regressions, we examined the contribution of tract-FA at age 6 to reading outcome at age 8, beyond known demographic and pre-literacy predictors of reading. Tract-FA of the left arcuate, left and right superior longitudinal fasciculus (SLF), and left inferior cerebellar peduncle (ICP) made unique contributions to reading outcome after consideration of sex and family history of reading delays. Tract-FA of the left and right SLF and left ICP made unique contributions to reading outcome after the addition of pre-literacy skills. Thus, cerebellar and bilateral cortical pathways represented a network associated with subsequent reading abilities. Early white matter properties may be associated with other neuropsychological functions that predict reading or may influence reading development, independent of reading-related abilities. Tract FA at early stages of learning to read may serve as a biomarker of later reading abilities.