Electrical cross-sectional imaging of human motor units in vivo
Electrical cross-sectional imaging of human motor units in vivo
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DOI：
10.1016/j.clinph.2021.12.022
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发表时间：
2022-04-01
影响因子：
4.7
通讯作者：
Whittaker, Roger
中科院分区：
文献类型：
--
作者：
Maitland, Stuart;Escobedo-Cousin, Enrique;Whittaker, Roger
目的：在许多神经肌肉疾病中，肌无力是由于运动单位内肌纤维排列的中断而引起的。在目前的技术的局限性意味着，在人体运动units.Methods：一个灵活的多通道电极的空间分布的纤维仍然是未知的，并结合到临床肌电图（EMG）针。肌纤维动作电位的本地化使用一种新的去卷积方法。这是使用模拟数据进行测试，并在记录收集的健康subjects.Results胫骨前肌：模拟数据表明良好的本地化可靠性在所有部分的电极，除了结束部分。校正后的纤维密度估计为1.4纤维/mm（2）。在三个人的五个记录中，检测到4到14个运动单位。1和20之间的肌肉纤维被定位每个电机单元内的电极检测area.Conclusions，与多达220个肌肉纤维定位每个记录，重叠电机单元的区域：我们提供了第一个直接的证据，人类的运动单位空间重叠，以及相关的数据在一个电机单元内的肌肉纤维的空间排列。(c)2022国际临床神经生理学联合会。由爱思唯尔公司出版
Objectives: In many neuromuscular diseases, weakness results from a disruption in muscle fibres' arrangement within a motor unit. Limitations in current techniques mean that the spatial distribution of fibres in human motor units remains unknown.Methods: A flexible multi-channel electrode was developed and bonded to a clinical electromyography (EMG) needle. Muscle fibre action potentials were localised using a novel deconvolution method. This was tested using simulated data, and in recordings collected from the tibialis anterior muscle of healthy subjects.Results: Simulated data indicated good localisation reliability across all sections of the electrode except the end sections. A corrected fibre density was estimated up to 1.4 fibres/mm(2). Across five recordings from three individuals, between 4 and 14 motor units were detected. Between 1 and 20 muscle fibres were localised per motor unit within the electrode detection area, with up to 220 muscle fibres localised per recording, with overlapping motor unit territories.Conclusions: We provide the first direct evidence that human motor units spatially overlap, as well as data related to the spatial arrangement of muscle fibres within a motor unit. (c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.