SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
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DOI：
10.7554/elife.18206
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发表时间：
2016-11-22
期刊：
影响因子：
7.7
通讯作者：
Elmquist, Joel K.
中科院分区：
文献类型：
--
作者：
Fujikawa, Teppei;Castorena, Carlos M.;Elmquist, Joel K.
运动对新陈代谢有许多有益的影响。中枢神经系统（CNS）是调节能量平衡和协调全身代谢的关键。然而，在运动的背景下，中枢神经系统在代谢调节中的作用仍然不太清楚。在这里，我们使用基因工程小鼠评估了类固醇生成因子-1 （SF-1）在腹内侧下丘脑核（VMH）神经元中表达的需求，以介导运动对代谢的有益影响。我们发现，vmh特异性的SF-1缺失会减弱(a)脂肪量的减少，(b)血糖的改善，以及(c)与运动训练相关的能量消耗的增加。出乎意料的是，我们发现VMH中SF-1的缺失会减弱骨骼肌对运动的代谢反应，包括诱导PGC-1 α的表达。总的来说，这些证据表明，运动对新陈代谢的有益影响需要VMH神经元中SF-1的表达。
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1 alpha expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism.