Alcohol rapidly lowers plasma testosterone levels in the rat: evidence that a neural brain-gonadal pathway may be important for decreased testicular responsiveness to gonadotropin.
Alcohol rapidly lowers plasma testosterone levels in the rat: evidence that a neural brain-gonadal pathway may be important for decreased testicular responsiveness to gonadotropin.
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酒精会迅速降低大鼠的血浆睾酮水平：证据表明神经脑-性腺途径可能对于降低睾丸对促性腺激素的反应性很重要。
DOI：
10.1111/j.1530-0277.1999.tb04021.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Rivier,C
中科院分区：
文献类型：
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作者：
Rivier,C
据报道，酒精可抑制成年雄性大鼠的睾酮(T)分泌。黄体生成素（LH）循环水平和/或睾丸甾体生成酶活性的降低被认为是这种抑制作用的可能机制。我们最近提供了大脑和男性性腺之间的神经通路的功能证据，该通路在脑促炎细胞因子钝化睾丸对人绒毛膜促性腺激素（hCG）的反应能力中起重要作用。目前的工作旨在验证一种假设，即类似的途径可能涉及酒精对T分泌的抑制作用。酒精，腹腔或灌胃给药，显著阻止T对促性腺激素的反应。这种效果在药物治疗后15分钟内显著。在胃内模型（唯一用于这类实验的模型）中，酒精的作用不会因事先阻断LH释放而改变，这表明它与垂体促性腺激素活性的变化无关。腹腔注射酒精的最低有效剂量为2.0 g/kg。脑室内注射α和β -肾上腺素能受体拮抗剂酚妥拉明和普萘洛尔在hCG前15分钟显著逆转酒精的抑制作用，而不是60分钟。总的来说，我们的结果表明：(1)酒精诱导血浆T水平迅速而深刻的下降，这是继发于睾丸对hCG的反应性下降；(2)酒精的这种急性抑制作用至少部分可能依赖于大脑和睾丸之间的神经、肾上腺素能依赖通路的激活。
Alcohol is reported to suppress testosterone (T) secretion in the adult male rat. Decreases in the circulating levels of luteinizing hormone (LH) and/or the activity of testicular steroidogenic enzymes have been proposed as putative mechanisms underlying this inhibitory effect. We have recently provided functional evidence for a neural pathway between the brain and the male gonads that plays an important role in the ability of brain proinflammatory cytokines to blunt testicular responsiveness to human chorionic gonadotropin (hCG). The present work was designed to test the hypothesis that a similar pathway might be implicated in the inhibitory influence of alcohol on T secretion. Alcohol, administered intraperitoneally or intragastrically, significantly prevented the T response to the gonadotropin. This effect was significant within 15 min of drug treatment. In the intragastric model (the only one used for this type of experiment), the effect of alcohol was not altered by prior blockade of LH release, which suggests that it is independent of changes in the activity of the pituitary gonadotrophs. The lowest effective dose of alcohol, delivered intraperitoneally, was 2.0 g/kg. The intracerebroventricular injection of the α and β‐adrenergic receptor antagonists phentolamine and propranolol significantly reversed the inhibitory influence of alcohol when it was administered 15 min, but not 60 min, before hCG. Collectively, our results indicate that (1) alcohol induces a rapid and profound decrease in plasma T levels that is secondary to decreased testicular responsiveness to hCG; and (2) at least part of this acute inhibitory action of alcohol may depend on the activation of a neural, adrenergic‐dependent pathway between the brain and the testes.