Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy
Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy
复制标题
DOI：
10.1212/01.wnl.0000179003.95838.71
复制
发表时间：
2005-10-11
期刊：
影响因子：
9.9
通讯作者：
Thompson, PM
中科院分区：
文献类型：
--
作者：
Lin, JJ;Salamon, N;Thompson, PM
作者使用基于表面的解剖映射来检测海马解剖特征，这些特征与接受手术治疗内侧颞叶癫痫合并海马硬化患者的手术结果相关。与无癫痫发作组相比，非癫痫发作组的海马剖面具有更大的弥漫性同侧萎缩和更多的区域特异性对侧海马前部和外侧萎缩。这些萎缩区域可能表明癫痫性增加的区域，导致较差的手术结果。
The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.