Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke
Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke
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DOI：
10.1007/s100720070114
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发表时间：
2000-02-01
影响因子：
3.3
通讯作者：
Lenzi, GL
中科院分区：
文献类型：
--
作者：
Bragoni, M;Altieri, M;Lenzi, GL
本研究的目的是探讨溴隐亭（BR）联合语言治疗（ST）对改善非流利失语脑卒中患者的晚期康复的疗效。我们进行了一项双盲研究，使用高剂量的BR，根据剂量递增方案处方，综合临床数据、亲属印象和语言评估。研究分为以下阶段：t-0，纳入；T-30，语言重测评估失语稳定性；t-90，安慰剂（PL）和ST；t-150、BR、ST；t - 210, BR;t - 270,没有用。在基线评估方面，在以下测试中观察到显著改善：听写(F, 4.8; p
The objectives of this study were to investigate the efficacy of bromocriptine (BR) combined with speech therapy (ST) to improve a late recovery in non-fluent aphasic stroke patients. We performed a double-blind study with high dosage of BR, prescribed according to a dose-escalating protocol, comprehensive of clinical data, relatives' impression, and language evaluations. The study was divided into the following phases: t-0, inclusion; t-30, language re-test to evaluate the stability of aphasia; t-90, placebo (PL) and ST; t-150, BR and ST; t-210, BR; t-270, wash-out. With respect to the baseline assessment, a significant improvement was observed in the following tests: dictation (F, 4.8; p